Comparison between titanium and anatase miRNAs regulation.
Comparison between titanium and anatase miRNAs regulation.
复制标题
DOI：
10.1016/j.nano.2007.03.004
复制
发表时间：
2007-06
期刊：
影响因子：
--
通讯作者：
A. Palmieri;G. Brunelli;Laura Guerzoni;L. Lo Muzio;A. Scarano;C. Rubini;L. Scapoli;M. Martinelli;F. Pezzetti;F. Carinci
中科院分区：
文献类型：
--
作者：
A. Palmieri;G. Brunelli;Laura Guerzoni;L. Lo Muzio;A. Scarano;C. Rubini;L. Scapoli;M. Martinelli;F. Pezzetti;F. Carinci
钛具有良好的机械和化学性能，是假体材料中的黄金标准。二氧化钛有三种同素异形体：钛铁矿、金红石和锐钛矿。锐钛矿可以制备成胶体悬浮液，并用于表面涂层。锐钛矿涂层(AC)可能具有潜在的生物效应，并特异性地诱导骨形成。为了获得更多关于AC与钛相比的成骨作用的信息，我们使用microRNA(MiRNA)微阵列技术研究了钛和AC对成骨细胞的翻译调节。有3个上调的miRNAs(mir-1、mir-34c、mir-210)和8个下调的miRNAs(mir-23b、mir-377、mir-22、mir-93、mir-422b、mir-17-5p、mir-24、mir-130b)的假发现率为0，评分为3。
Titanium is the gold standard among materials used for prosthetic devices because of its good mechanical and chemical properties. There are three allotropic forms of titanium dioxide: brookite, rutile, and anatase. Anatase can be prepared as a colloidal suspension and used to coat surfaces. Anatase coating (AC) can potentially have biological effects and specifically can induce bone formation. To obtain more information about the osteogenic effect of AC in comparison to to titanium we used microRNA (miRNA) microarray techniques to investigate the translation regulation in osteoblasts exposed to both titanium and AC. There were three upregulated miRNAs (mir-1, mir-34c, mir-210) and eight downregulated miRNAs (mir-23b, mir-377, mir-22, mir-93, mir-422b, mir-17-5p, mir-24, mir-130b) for false discovery rate = 0 and score >3. The data reported are relevant to understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects.