ExoCarta as a resource for exosomal research.
ExoCarta as a resource for exosomal research.
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exocarta是外泌体研究的资源。
DOI：
10.3402/jev.v1i0.18374
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发表时间：
2012
影响因子：
16
通讯作者：
Mathivanan S
中科院分区：
文献类型：
--
作者：
Simpson RJ;Kalra H;Mathivanan S
外泌体是由各种细胞类型分泌的一类细胞外囊泡。与其他细胞外囊泡（外体和凋亡泡）不同，外泌体是内吞起源的。外泌体在疫苗/药物递送、细胞间通讯以及作为疾病生物标志物的可能来源中的作用引发了人们对它们的极大兴趣，导致了大量的研究。虽然多维数据集是不断生成的，但很难利用数据的真正潜力，直到它们被编译并提供给生物医学研究人员。在这里，我们描述了ExoCarta（http：www.exocarta.org），一个人工管理的外泌体蛋白、RNA和脂质数据库。目前ExoCarta中的数据集来自已发表和未发表的外泌体研究。自2009年推出以来，ExoCarta已被16，000多名独立用户访问。在这篇文章中，我们讨论了ExoCarta用于外泌体研究的实用性，并敦促该领域的生物医学研究人员将他们的数据集直接存款ExoCarta。
Exosomes are a class of extracellular vesicles that are secreted by various cell types. Unlike other extracellular vesicles (ectosomes and apoptotic blebs), exosomes are of endocytic origin. The roles of exosomes in vaccine/drug delivery, intercellular communication and as a possible source of disease biomarkers have sparked immense interest in them, resulting in a plethora of studies. Whilst multidimensional datasets are continuously generated, it is difficult to harness the true potential of the data until they are compiled and made accessible to the biomedical researchers. Here, we describe ExoCarta (http://www.exocarta.org), a manually curated database of exosomal proteins, RNA and lipids. Datasets currently present in ExoCarta are integrated from both published and unpublished exosomal studies. Since its launch in 2009, ExoCarta has been accessed by more than 16,000 unique users. In this article, we discuss the utility of ExoCarta for exosomal research and urge biomedical researchers in the field to deposit their datasets directly to ExoCarta.