Iron metabolism in infections: Focus on COVID-19.
Iron metabolism in infections: Focus on COVID-19.
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DOI：
10.1053/j.seminhematol.2021.07.001
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发表时间：
2021-07
影响因子：
3.6
通讯作者：
Vianello A
中科院分区：
文献类型：
--
作者：
Girelli D;Marchi G;Busti F;Vianello A
铁是几乎所有生物体中广泛代谢过程所必需的微量营养素。在感染过程中，人类宿主和入侵的病原体之间发生了一场争夺铁的战争。肝肽hepcidin在遗传学和结构上与防御素（先天免疫的抗微生物肽）相连，通过将铁螯合到宿主细胞（主要是巨噬细胞）中而将铁减少到病原体中而发挥关键作用。虽然这种现象在某些细菌感染中得到了很好的研究，但对于病毒感染知之甚少。铁代谢也对免疫系统细胞的功能有影响。一旦通过与抗原呈递细胞接触而引发，淋巴细胞需要铁来维持建立有效的细胞和体液应答所需的代谢爆发。COVID-19大流行推动了大量的临床和转化研究，研究营养素对SARS-CoV-2感染的可能影响，无论是易感性还是临床病程。在这里，我们回顾了铁代谢和COVID-19之间的交叉点，属于所谓的“营养免疫”的更广泛的领域。更好地理解这种联系具有潜在的广泛意义，无论是从机械的角度来看，还是为了制定更有效的策略来管理COVID-19和未来可能的大流行病。
Iron is a micronutrient essential for a wide range of metabolic processes in virtually all living organisms. During infections, a battle for iron takes place between the human host and the invading pathogens. The liver peptide hepcidin, which is phylogenetically and structurally linked to defensins (antimicrobial peptides of the innate immunity), plays a pivotal role by subtracting iron to pathogens through its sequestration into host cells, mainly macrophages. While this phenomenon is well studied in certain bacterial infections, much less is known regarding viral infections. Iron metabolism also has implications on the functionality of cells of the immune system. Once primed by the contact with antigen presenting cells, lymphocytes need iron to sustain the metabolic burst required for mounting an effective cellular and humoral response. The COVID-19 pandemic has boosted an amount of clinical and translational research over the possible influences of nutrients on SARS-CoV-2 infection, in terms of either susceptibility or clinical course. Here we review the intersections between iron metabolism and COVID-19, belonging to the wider domain of the so-called “nutritional immunity”. A better understanding of such connections has potential broad implications, either from a mechanistic standpoint, or for the development of more effective strategies for managing COVID-19 and possible future pandemics.
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DOI：
10.1016/j.medj.2020.10.004
发表时间：
2021-02-12
期刊：
Med (New York, N.Y.)
影响因子：
--
作者：
Frost JN;Tan TK;Abbas M;Wideman SK;Bonadonna M;Stoffel NU;Wray K;Kronsteiner B;Smits G;Campagna DR;Duarte TL;Lopes JM;Shah A;Armitage AE;Arezes J;Lim PJ;Preston AE;Ahern D;Teh M;Naylor C;Salio M;Gileadi U;Andrews SC;Dunachie SJ;Zimmermann MB;van der Klis FRM;Cerundolo V;Bannard O;Draper SJ;Townsend ARM;Galy B;Fleming MD;Lewis MC;Drakesmith H
通讯作者：
Drakesmith H
影响因子：
2.1
作者：
Ganz, Tomas
通讯作者：
Ganz, Tomas
影响因子：
64.8
作者：
Al-Aly, Ziyad;Xie, Yan;Bowe, Benjamin
通讯作者：
Bowe, Benjamin
影响因子：
7.5
作者：
Flannagan, Ronald S.;Farrell, Tayler J.;Heinrichs, David E.
通讯作者：
Heinrichs, David E.
影响因子：
82.9
作者：
Brodin, Petter
通讯作者：
Brodin, Petter