Evidence of increased nitric oxide production in patients with the sepsis syndrome.
Evidence of increased nitric oxide production in patients with the sepsis syndrome.
复制标题
脓毒症综合征患者一氧化氮生成增加的证据。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
J. Cohen
中科院分区：
文献类型：
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作者：
T. Evans;A. Carpenter;H. Kinderman;J. Cohen
为了探讨感染性休克低血压是否是由于一氧化氮（NO）的过量产生，我们测定了12例败血症综合征和明显低血压患者血清中NO的稳定终产物硝酸盐和亚硝酸盐（NO_3/NO_2）的水平。与对照组（n = 7）的平均NO3/NO2水平36.4 microM相比，脓毒症患者组的平均NO3/NO2水平显著升高至124 microM（P < 0.01，Wilcoxon双样本检验）。在一组术后患者中也观察到较小的升高（平均水平87.3 microM，n = 7），其与对照组相比显著升高（P < 0.01，Wilcoxon双样本检验），但不显著低于脓毒症组（0.1 > P > 0.05，Wilcoxon双样本检验）。这些数据表明，NO可能是负责，至少部分，低血压的感染性休克。
To investigate whether the hypotension of septic shock is due to an excess production of nitric oxide (NO), we have determined the serum levels of nitrate and nitrite (NO3/NO2), the stable end-products of NO, in 12 patients with the sepsis syndrome and marked hypotension. Compared to a mean NO3/NO2 level of 36.4 microM in controls (n = 7), the group of septic patients had a significantly elevated mean NO3/NO2 level of 124 microM (P < 0.01, Wilcoxon two-sample test). A lesser elevation was also seen in a group of postoperative patients (mean level 87.3 microM, n = 7), which was significantly elevated compared to controls (P < 0.01, Wilcoxon two-sample test), but was not significantly lower than the septic group (0.1 > P > 0.05, Wilcoxon two-sample test). These data suggest that NO may be responsible, at least in part, for the hypotension of septic shock.