A case of cortisol producing adrenal adenoma associated with a latent aldosteronoma: usefulness of the ACTH loading test for the detection of covert aldosteronism in overt Cushing syndrome.
A case of cortisol producing adrenal adenoma associated with a latent aldosteronoma: usefulness of the ACTH loading test for the detection of covert aldosteronism in overt Cushing syndrome.
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与潜在醛固酮瘤相关的产生皮质醇的肾上腺腺瘤病例：ACTH 负荷试验在检测明显库欣综合征中隐性醛固酮增多症中的作用。
DOI：
10.2169/internalmedicine.51.5597
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发表时间：
2012
影响因子：
1.2
通讯作者：
E. Araki
中科院分区：
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作者：
D. Kukidome;N. Miyamura;K. Sakakida;S. Shimoda;Y. Shigematu;K. Nishi;Y. Yamashita;M. Eto;H. Sasano;E. Araki
一名36岁的女性库欣综合征进行了评估共存的醛固酮增多症，这是由异常反应的醛固酮皮质醇比率在外周血中的促肾上腺皮质激素管理，尽管低的基础醛固酮与肾素的比例。计算机断层扫描显示左肾上腺有两个独立的肿瘤，肾上腺静脉取样显示除同侧皮质醇增多外，还存在醛固酮增多症。术后研究，包括类固醇生成酶的免疫组化分析表明，一个腺瘤是皮质醇生产和其他，醛固酮生产。这些不同的分泌性腺瘤的合并症并不罕见，术前仔细评估是必要的，以避免术后潜伏性醛固酮增多症的恶化。
A 36-year-old woman with Cushing syndrome was evaluated for coexisting hyperaldosteronism, which was suggested by an abnormal response of the aldosterone-to-cortisol ratio in peripheral blood to the ACTH-administration despite a low basal aldosterone-to-renin ratio. Computed tomography revealed two independent tumors in the left adrenal gland, and adrenal venous sampling indicated hyperaldosteronism in addition to hypercortisolism in the same side. Postsurgical study including immunohistochemical analysis of steroidogenic enzymes suggested one adenoma to be cortisol-producing and the other, aldosterone-producing. The comorbidity of these different hormone-producing adenomas is not rare and careful pre-surgical evaluation is necessary to avoid post-surgical exacerbation of latent hyperaldosteronism.
“减法电位差：快速可靠的盐皮质激素活性体内测定方法。”
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