Interferon-Stimulated Genes: What Do They All Do?
Interferon-Stimulated Genes: What Do They All Do?
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DOI：
10.1146/annurev-virology-092818-015756
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Schoggins, John W.
中科院分区：
文献类型：
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作者：
Schoggins, John W.
在没有完整的干扰素（IFN）反应的情况下，哺乳动物可能对致命的病毒感染易感。IFN是一种分泌的细胞因子，其激活信号转导级联，导致数百个干扰素刺激基因（ISG）的诱导。值得注意的是，人类基因组中大约10%的基因具有受IFN调控的潜力。所有这些基因都做了什么？这是一个复杂的问题，没有简单的答案。从几十年的研究中，我们知道这些ISG编码的许多蛋白质产物单独或协同工作，以实现一种或多种细胞结果，包括抗病毒防御，抗增殖活性和刺激适应性免疫。本文就IFN/ISG系统的抗病毒活性作一综述。这包括ISG功能的一般范例，在文献中的具体例子，以及方法来识别和表征ISG功能的支持。
In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal viral infection. IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs). Remarkably, approximately 10% of the genes in the human genome have the potential to be regulated by IFNs. What do all of these genes do? It is a complex question without a simple answer. From decades of research, we know that many of the protein products encoded by these ISGs work alone or in concert to achieve one or more cellular outcomes, including antiviral defense, antiproliferative activities, and stimulation of adaptive immunity. The focus of this review is the antiviral activities of the IFN/ISG system. This includes general paradigms of ISG function, supported by specific examples in the literature, as well as methodologies to identify and characterize ISG function.