The Multivalent Nature of Growth Hormone
The Multivalent Nature of Growth Hormone
复制标题
生长激素的多价性质
DOI：
10.1007/978-1-4615-7201-5_35
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发表时间：
1986
影响因子：
3.1
通讯作者：
J. Kostyo
中科院分区：
文献类型：
--
作者：
J. Kostyo
多年来，已知从多种哺乳动物物种中分离的垂体生长激素（GH）制剂表现出多种生物学特性，这些特性难以与激素的一种共同作用机制相协调。大多数GH制剂不仅是合成代谢的，而且可能是致糖尿病的，在某些物种如狗和人中产生高血糖症和葡萄糖耐受不良，并在许多物种中引起高胰岛素血症和胰岛素抵抗。此外，在GH缺乏的受试者中，这些GH制剂产生短暂的胰岛素样作用，包括诱导低血糖，这是由于刺激外周组织的葡萄糖摄取和利用以及抑制脂解所致。最后，灵长类动物的GH制剂也是催乳的，而亚灵长类动物的GH制剂不是。
It has been known for many years that pituitary growth hormone (GH) preparations isolated from a variety of mammalian species exhibit multiple biological properties that are difficult to reconcile with one common mechanism of action of the hormone. Most GH preparations are not only anabolic but can be diabetogenic, producing hyperglycemia and glucose intolerance in certain species such as the dog and man and causing hyperinsulinemia and insulin resistance in many species. Moreover, in GH-deficient subjects, these GH preparations produce transient insulinlike effects, including the induction of hypoglycemia, resulting from the stimulation of glucose uptake and utilization by peripheral tissues and the inhibition of lipolysis. Finally, primate GH preparations are also lactogenic, whereas those of infraprimates are not.