Representation of Geometric Borders in the Developing Rat
Representation of Geometric Borders in the Developing Rat
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DOI：
10.1016/j.neuron.2014.02.014
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发表时间：
2014-04-02
期刊：
影响因子：
16.2
通讯作者：
Moser, May-Britt
中科院分区：
文献类型：
--
作者：
Bjerknes, Tale L.;Moser, Edvard I.;Moser, May-Britt
局部空间由许多功能特异的细胞类型表示，包括海马中的位置细胞和内侧内嗅皮层（MEC）中的网格细胞、头部方向细胞和边界细胞。这些细胞形成了一个外部空间的功能地图，当幼鼠在2.5周龄时第一次离开巢穴时。然而，虽然位置细胞从一开始就具有成人般的放电场，但网格细胞直到第四周才具有不规则和可变的场，这引起了人们对它们在年轻时对位置细胞放电的贡献的怀疑。记录在MEC的幼年大鼠，我们发现，不像网格细胞，边缘细胞表达成人样的发射场从暴露于开放环境的第一天，在出生后第16-18天。因此，来自边缘细胞的空间信号可能足以维持幼年海马位置细胞的空间定位放电。
Local space is represented by a number of functionally specific cell types, including place cells in the hippocampus and grid cells, head direction cells, and border cells in the medial entorhinal cortex (MEC). These cells form a functional map of external space already at the time when rat pups leave the nest for the first time in their life, at the age of 2.5 weeks. However, while place cells have adultlike firing fields from the outset, grid cells have irregular and variable fields until the fourth week, raising doubts about their contribution to place cell firing at young age. Recording in MEC of juvenile rats, we show that, unlike grid cells, border cells express adult-like firing fields from the first days of exposure to an open environment, at postnatal days 16-18. Thus, spatial signals from border cells may be sufficient to maintain spatially localized firing in juvenile hippocampal place cells.