Saroclides A and B, Cyclic Depsipeptides from the Mangrove-Derived Fungus Sarocladium kiliense HDN11-112
Saroclides A and B, Cyclic Depsipeptides from the Mangrove-Derived Fungus Sarocladium kiliense HDN11-112
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Saroclides A 和 B，来自红树林衍生真菌 Sarocladium kiliense HDN11-112 的环缩肽
DOI：
10.1021/acs.jnatprod.7b00644
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发表时间：
2018-04-01
影响因子：
5.1
通讯作者：
Li, Dehai
中科院分区：
文献类型：
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作者：
Guo, Wenqiang;Wang, Shuai;Li, Dehai
从红树林真菌Sarocladium kiliense HDN 11 -112的提取物中发现了两个新的缩肽（1和2），以及三个已知的相关化合物pestalotin（3）、pestalotiopyrone L（4）和PC-2（5）。通过大量的NMR光谱数据和X-射线晶体学分析，确定了saroclides A和B的结构。化合物1也由Simplicillium lamellicola HDN 13 -430产生。化合物1和2对五种癌细胞系和四种病原微生物无活性，而化合物1显示出降脂作用。
Two new depsipeptides (1 and 2), together with three known related compounds, pestalotin (3), pestalotiopyrone L (4), and PC-2 (5), were discovered in the extract of a mangrove derived fungus Sarocladium kiliense HDN11-112. The structures of saroclides A and B were established by interpretation of extensive NMR spectroscopic data and X-ray crystallographic analysis. Compound 1 was also produced by Simplicillium lamellicola HDN13-430. Compounds 1 and 2 were inactive against five cancer cell lines and four pathogenic microorganisms, while compound 1 showed a lipid-lowering effect.