Advances in community-acquired pneumonia.
Advances in community-acquired pneumonia.
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DOI：
10.1177/2049936120969607
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发表时间：
2020-01
影响因子：
5.7
通讯作者：
Waterer G
中科院分区：
文献类型：
--
作者：
Jones B;Waterer G
社区获得性肺炎是最常见和最致命的传染病之一，但我们对它的了解仍然相对较少。最近出版的美国胸科学会和美国传染病学会社区获得性肺炎指南承认，我们接受的大多数标准治疗仅得到低质量证据的支持，突出了我们知识的持续不确定性和不足。然而，诊断学、转化研究和流行病学的进展改变了我们对肺炎的概念，有助于逐步改善患者的预防、诊断、治疗和预后。大量关于肺炎幸存者不良长期健康结果的证据的出现也挑战了我们将肺炎作为急性疾病的概念以及治疗终点的重要性。本文综述了近20年来社区获得性肺炎的研究和护理进展。我们总结了我们对发病机制和诊断的理解的证据，讨论了关键的有争议的管理问题，包括降钙素原的作用和使用或不使用皮质类固醇，并探讨肺炎和长期结果之间的关系，包括心血管和认知健康。
Community-acquired pneumonia is one of the commonest and deadliest of the infectious diseases, yet our understanding of it remains relatively poor. The recently published American Thoracic Society and Infectious Diseases Society of America Community-acquired pneumonia guidelines acknowledged that most of what we accept as standard of care is supported only by low quality evidence, highlighting persistent uncertainty and deficiencies in our knowledge. However, progress in diagnostics, translational research, and epidemiology has changed our concept of pneumonia, contributing to a gradual improvement in prevention, diagnosis, treatment, and outcomes for our patients. The emergence of considerable evidence about adverse long-term health outcomes in pneumonia survivors has also challenged our concept of pneumonia as an acute disease and what treatment end points are important. This review focuses on advances in the research and care of community-acquired pneumonia in the past two decades. We summarize the evidence around our understanding of pathogenesis and diagnosis, discuss key contentious management issues including the role of procalcitonin and the use or non-use of corticosteroids, and explore the relationships between pneumonia and long-term outcomes including cardiovascular and cognitive health.
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影响因子：
5.9
作者：
Chalmers, James D.;Singanayagam, Aran;Hill, Adam T.
通讯作者：
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影响因子：
120.7
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DOI：
10.1164/rccm.200512-1922oc
发表时间：
2006-07-01
影响因子：
24.7
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3.6
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