TONIC ACTIVATION OF NMDA RECEPTORS BY AMBIENT GLUTAMATE ENHANCES EXCITABILITY OF NEURONS
TONIC ACTIVATION OF NMDA RECEPTORS BY AMBIENT GLUTAMATE ENHANCES EXCITABILITY OF NEURONS
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DOI：
10.1126/science.2573153
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发表时间：
1989-11-10
期刊：
影响因子：
56.9
通讯作者：
NICOLL, RA
中科院分区：
文献类型：
--
作者：
SAH, P;HESTRIN, S;NICOLL, RA
海马切片中锥体细胞的电压钳记录和噪声分析表明 N-甲基-D-天冬氨酸 (NMDA) 受体具有紧张活性。根据细胞外液中已知的谷氨酸浓度，这种强直作用可能是由环境谷氨酸水平引起的。 NMDA 受体对电压敏感，因此这些受体的背景激活赋予锥体细胞再生电特性，从而促进这些神经元中树突兴奋性突触输入和体细胞动作电位放电之间的耦合。
Voltage clamp recordings and noise analysis from pyramidal cells in hippocampal slices indicate that N-methyl-D-aspartate (NMDA) receptors are tonically active. On the basis of the known concentration of glutamate in the extracellular fluid, this tonic action is likely caused by the ambient glutamate level. NMDA receptors are voltage-sensitive, thus background activation of these receptors imparts a regenerative electrical property to pyramidal cells, which facilitates the coupling between dendritic excitatory synaptic input and somatic action potential discharge in these neurons.