Immune components of the intestinal mucosae of ageing and protein deficient mice.
Immune components of the intestinal mucosae of ageing and protein deficient mice.
复制标题
衰老和蛋白质缺乏小鼠肠粘膜的免疫成分。
作者：
T. Lim;Nadia Messiha;Ronald R. Watson
本研究旨在研究衰老和低蛋白（4%）饮食对肠道抗体依赖性细胞介导的细胞毒性（ADCC）和IgA浓度的影响。ADCC活性和IgA浓度均显示在17周龄时达到成熟水平。衰老对ADCC活性的影响更大，在75周龄时ADCC活性急剧下降，而IgA在75周龄时浓度仅略有下降。低蛋白饲粮对IgA浓度的抑制作用大于对ADCC活性的抑制作用。随着喂养低蛋白幼鼠时间的延长，观察到肠道内IgA浓度下降幅度更大。老年小鼠和成年小鼠短期（8周）低蛋白饮食后，ADCC活性和IgA浓度与正常小鼠无显著差异。
The studies were designed to investigate the effect of ageing and low protein (4%) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) and IgA concentration in the intestine. Both ADCC activity and IgA concentration were shown to reach mature levels at 17 weeks old. The effect of ageing was greater on ADCC activity which showed a drastic drop in activity at 75 weeks old than IgA which had only a slight decline in concentration at this age. The low protein diet has a greater suppressive effect on IgA concentration than on ADCC activity. As the duration of feeding low protein to the young mice increased, greater decline in IgA concentration in the intestine was observed. There was, however, no significant difference from the normal mice in ADCC activity and IgA concentration of aged and adult mice given short term (8 weeks) low protein diet.