Melatonin for Spinal Cord Injury in Animal Models: A Systematic Review and Network Meta-Analysis
Melatonin for Spinal Cord Injury in Animal Models: A Systematic Review and Network Meta-Analysis
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褪黑素治疗动物模型脊髓损伤：系统评价和网络荟萃分析
DOI：
10.1089/neu.2015.4038
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发表时间：
2016
影响因子：
4.2
通讯作者：
Cui Xue-jun
中科院分区：
文献类型：
--
作者：
Yang Long;Yao Min;Lan Yun;Mo Wei;Sun Yue-li;Wang Jing;Wang Yong-jun;Cui Xue-jun
脊髓损伤 (SCI) 会导致病变下方的功能丧失，并影响全世界的个人。越来越多的实验研究支持褪黑激素 (MT) 对 SCI 的有效性。我们的目的是研究 MT 在 SCI 动物模型中的神经恢复和抗氧化作用，并探索合适的剂量。检索了六个数据库中描述的已发表的 SCI 动物模型 MT 研究。两名经验丰富的研究人员选择了研究，提取了数据，并独立评估了纳入研究的质量。一项荟萃分析评估了 MT 在 SCI 中的作用，并进行了网络荟萃分析以探索 SCI 模型的适当 MT 剂量。分析了十三项研究，其中三项是高质量的。荟萃分析结果显示，行为评价（Basso、Beattie、Bresnahan量表，n= 90，p= 0.003；运动功能评分，n= 92，p= 0.004；Tarlov标准，n= 150，p= 0.002；斜面测试，n= 150，p= 0.001）和生化结果（丙二醛，n= 121，p= 0.0010；谷胱甘肽水平，n= 64，p< 0.0001；和髓过氧化物酶活性，n= 32，p< 0.00001）与对照组相比有所改善， MT 给药后。 12.5mg/kg 的剂量对 SCI 大鼠模型最有效。研究表明，MT 给药可显着改善 SCI 大鼠模型的神经恢复和抗氧化作用。对于SCI大鼠模型，MT的合适剂量为12.5mg/kg。大多数纳入的研究质量较低；然而，脊髓损伤的最佳 MT 治疗仍需要高质量的研究。
Spinal cord injury (SCI) leads to loss of function below the lesion and affects individuals worldwide. An increasing number of experimental studies support the effectiveness of melatonin (MT) for SCI. Our objectives were to investigate neurological recovery and anti-oxidant effects of MT in animal models of SCI, and to explore the appropriate dose. Published MT studies in SCI animal models described in six databases were searched. Two practiced investigators selected the studies, extracted the data, and independently evaluated the quality of the included studies. A meta-analysis evaluated the effect of MT in SCI and a network meta-analysis was performed to explore the appropriate MT dose for SCI models. Thirteen studies were analyzed, of which three were high quality. The results of the meta-analysis manifested that the behavioral evaluation (Basso, Beattie, and Bresnahan scales,n= 90,p= 0.003; motor function scores,n= 92,p= 0.004; Tarlov's criteria,n= 150,p= 0.002; inclined plane test,n= 150,p= 0.001) and biochemical outcomes (malondialdehyde,n= 121,p= 0.0010; glutathione levels,n= 64,p< 0.0001; and myeloperoxidase activity,n= 32,p< 0.00001) were improved, compared with the control group, after MT administration. A dose of 12.5 mg/kg was most effective in SCI rat models. Studies indicated that MT administration significantly improved neurological recuperation and anti-oxidant effects in rat models of SCI. The appropriate dose of MT was 12.5 mg/kg for SCI rat models. The majority of included studies were low quality; however, optimal MT treatment in SCI still requires high quality studies.