Role of prolactin in vitamin D metabolism and calcium absorption during lactation in the rat.
Role of prolactin in vitamin D metabolism and calcium absorption during lactation in the rat.
复制标题
催乳素在大鼠哺乳期间维生素 D 代谢和钙吸收中的作用。
作者：
Robinson Cj;E. Spanos;James Mf;J. Pike;M. Haussler;Makeen Am;C. Hillyard;I. Macintyre
测定泌乳和非泌乳大鼠肠道钙吸收和血浆1,25(OH)2D3 （1,25(OH)2D3）水平，并评价溴隐亭和外源性催乳素治疗的效果。哺乳期大鼠钙吸收、血浆甲状旁腺激素、1,25(OH)2D3水平和碱性磷酸酶活性均显著升高。溴隐亭可显著降低钙吸收、血浆1,25(OH)2D3和碱性磷酸酶水平，但对血浆甲状旁腺激素水平无显著影响。催乳素与溴隐亭联合施用于哺乳期动物可防止单独使用溴隐亭所观察到的所有变化。由此得出结论，哺乳期血浆泌乳水平的增加导致血浆中1,25(OH)2D3水平升高，这是肠道钙吸收增强的原因。
Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in lactating and non-lacting rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lacting rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)2D3 and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)2D3 and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolacting during lactation lead to high plasma levels of 1,25(OH)2D3 which are responsible for the enhanced intestinal calcium absorption.