Cobalt-catalyzed cross-dehydrogenative coupling between N-(2-pyridyl) and free indoles for the synthesis of unsymmetrical 2,2 '-biindoles
Cobalt-catalyzed cross-dehydrogenative coupling between N-(2-pyridyl) and free indoles for the synthesis of unsymmetrical 2,2 '-biindoles
复制标题
钴催化 N-(2-吡啶基) 和游离吲哚之间的交叉脱氢偶联合成不对称 2,2'-双吲哚
DOI：
10.1039/c8cc07659f
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发表时间：
2019
影响因子：
4.9
通讯作者：
Yang Ping
中科院分区：
文献类型：
--
作者：
Li Ting;Yang Yuhan;Li Bo;Yang Ping
开发了 N-(2-吡啶基)吲哚与游离吲哚的钴催化交叉脱氢偶联，用于构建具有优异区域选择性的不对称 2,2'-二吲哚。该策略更广泛的底物范围以及可去除的导向基团使得在有机合成中可以合成不对称的2,2'-双吲哚。
Cobalt-catalyzed cross-dehydrogenative coupling of N-(2-pyridyl) indoles with free indoles for the construction of unsymmetrical 2,2′-biindoles with excellent regioselectivity is developed. The broader substrate scope as well as the removable directing group of this strategy allows the synthesis of unsymmetrical 2,2′-biindoles to be accessible in organic synthesis.