Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice
Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice
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DOI：
10.1093/jn/132.7.2069
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发表时间：
2002-07-01
影响因子：
4.2
通讯作者：
Kimura, Y
中科院分区：
文献类型：
--
作者：
Kimura, Y
我研究了鲤鱼油、油酸、亚油酸和亚麻酸对脾内移植高转移性Lewis肺癌（LLC）肿瘤小鼠的肿瘤生长和肝脏转移的影响。鲤鱼油（每只小鼠0.1或0.2 mL）显著减少肿瘤生长和肝脏转移。100或1000 mg/L鲤鱼油抑制LLC细胞DNA合成，抑制1000 mg/L人皮肤微血管内皮细胞（HMVEC）的毛细血管样管形成，抑制10 ~ 1000 mg/L LLC细胞对HMVEC的粘附。鲤鱼油（0.2 mL /只）抑制Matrigel在体内添加血管内皮生长因子（VEGF）和肝素诱导的血管生成。鲤鱼油的抗肿瘤和抗转移作用可能与通过抑制LLC细胞对微血管内皮的粘附抑制LLC细胞DNA合成和血管生成有关。油酸（每只小鼠0.1或0.2 mL）显著抑制肝脏转移，但对原发性实体瘤生长无影响。油酸对体外和体内模型血管生成均有抑制作用。1000 μ mol/L油酸对LLC细胞的DNA合成有抑制作用，对HMVEC细胞的DNA合成无影响。油酸的这些抑制作用可能与抑制肿瘤诱导的血管生成有关。亚油酸和亚麻酸对肿瘤生长和肝脏转移无影响。
I examined the effects of carp oil, oleic acid, linoleic acid and linolenic acid on tumor growth and metastasis to the liver in mice implanted intrasplenically with highly metastatic Lewis lung carcinoma (LLC) tumors. Carp oil (0.1 or 0.2 mL per mouse) significantly reduced tumor growth and metastasis to the liver. Carp oil at 100 or 1000 mg/L inhibited the DNA synthesis in LLC cells, the capillary-like tube formation of human dermal microvascular endothelial cells (HMVEC) at 1000 mg/L and the adherence of LLC cells to HMVEC at 10 to 1000 mg/L (in vitro). Carp oil (0.2 mL per mouse) inhibited the angiogenesis induced by Matrigel supplemented with vascular endothelial growth factor (VEGF) and heparin (in vivo). Antitumor and antimetastatic actions of carp oil might be partly attributable to the inhibition of DNA synthesis in LLC cells and angiogenesis through the inhibition of the adherence of LLC cells to the microvascular endothelium. Oleic acid (0.1 or 0.2 mL per mouse) significantly inhibited the metastasis to the liver, but it had no effect on the primary solid-tumor growth. Oleic acid inhibited the angiogenesis in both in vitro and in vivo models. Oleic acid at 1000 mumol/L inhibited the DNA synthesis in LLC cells but did not affect the DNA synthesis in HMVEC. These inhibitory actions of oleic acid may be attributable to the inhibition of anglogenesis induced by the tumor. Linoleic acid and linolenic acid had no effect on tumor growth or metastasis to the liver.