Frequency of ovarian cysts in patients with autosomal dominant polycystic kidney disease.
Frequency of ovarian cysts in patients with autosomal dominant polycystic kidney disease.
复制标题
常染色体显性多囊肾病患者卵巢囊肿的发生频率。
DOI：
10.1016/s0272-6386(99)70117-4
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Gabow,PA
中科院分区：
文献类型：
--
作者：
Stamm,ER;Townsend,RR;Johnson,AM;Garg,K;Manco-Johnson,M;Gabow,PA
常染色体显性遗传性多囊肾病（ADPKD）患者的肾外囊肿最常见于肝脏。卵巢囊肿在患有ADPKD的女性中有报道，但其频率尚未确定。因此，我们分析了数据库中337名患有ADPKD的女性及其199名未受影响的女性家庭成员（NADPKD）的历史数据。此外，我们前瞻性地研究了25名未怀孕、绝经前的ADPKD妇女和25名未怀孕、绝经前、年龄匹配的对照妇女，以评估卵巢囊肿的发生率。在对照组和ADPKD组中没有妇女接受外源性雌激素或孕激素。所有女性均接受了使用5或7.5 MHz阴道探头的超声检查。正常卵泡定义为平均直径小于2 cm的充满液体的结构，卵巢囊肿定义为2 cm或更大。从病史资料看，ADPKD组有卵巢囊肿病史者占28%，NADPKD组有卵巢囊肿病史者占18%（P < 0.05）。在前瞻性研究中，ADPKD女性患者的平均年龄与对照组女性患者的平均年龄无差异（40.9 ± 1.2岁vs 39.3 ± 1.2岁; P =无显著性[NS]）。在ADPKD组和对照组中，正常卵泡的频率没有差异（80%对96%; P = NS），在ADPKD组和对照组中，卵巢囊肿的频率也没有差异（12%对12%; P = NS）。ADPKD组和对照组的卵巢体积无差异（9.9 ± 2.5 vs 7.2 ± 1.2 cm 3）。在患有ADPKD的女性中，平均卵巢体积和平均肾脏体积之间没有相关性，肝囊性疾病的发生与卵巢囊肿之间也没有显著关系。因此，一项前瞻性的影像学研究表明，与普通人群相比，ADPKD女性的卵巢囊肿发生率并没有增加。
Extrarenal cysts occur in patients with autosomal dominant polycystic kidney disease (ADPKD) most frequently in the liver. Ovarian cysts have been reported in women with ADPKD, but their frequency has not been determined. Therefore, we analyzed the historical data in our database of 337 women with ADPKD and 199 of their unaffected female family members (NADPKD). In addition, we prospectively studied 25 nonpregnant, premenopausal women with ADPKD and 25 nonpregnant, premenopausal, age-matched control women recruited from the general population to assess the occurrence of ovarian cysts. No women in either the control or ADPKD groups were receiving exogenous estrogen or progesterone. All women underwent sonographic examination using a 5- or 7.5-MHz vaginal probe. A normal ovarian follicle was defined as a fluid-filled structure less than 2 cm in average diameter, and an ovarian cyst as one of 2 cm or greater. From the historical data, 28% of the women with ADPKD gave a history of ovarian cysts compared with 18% of the NADPKD women (P < 0.05). In the prospective study, the mean age of the women with ADPKD was not different from that of the control women (40.9 ± 1.2 v 39.3 ± 1.2 years; P = not significant [NS]). There was no difference in frequency of normal follicles found in women with ADPKD or controls (80% v 96%; P = NS), nor was there a difference in the frequency of ovarian cysts found in women with ADPKD or controls (12% v 12%; P = NS). There was no difference in the calculated ovarian volumes between the women with ADPKD and controls (9.9 ± 2.5 v 7.2 ± 1.2 cm3). Among the women with ADPKD, there was no correlation between mean ovarian volume and mean renal volume, nor was there a significant relationship between the occurrence of hepatic cystic disease and ovarian cysts. Therefore, a prospective imaging study suggests that ovarian cysts have no increased frequency in women with ADPKD compared with women in the general population.