Microbiological and serological investigations of oral lesions in Papillon-Lefevre syndrome
Microbiological and serological investigations of oral lesions in Papillon-Lefevre syndrome
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DOI：
10.1136/jcp.49.3.255
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发表时间：
1996-03-01
影响因子：
3.4
通讯作者：
Bird, PS
中科院分区：
文献类型：
--
作者：
Clerehugh, V;Drucker, DB;Bird, PS
对两名患有Papillon-Lefevre综合征的亚洲儿童进行了微生物学和血清学（酶联免疫吸附试验）调查，包括核型分析。在病例1中，一个4岁的女孩，最常见的假定牙周病原体是腐蚀艾肯氏菌、具核梭杆菌、牙龈卟啉单胞菌、中间普雷沃氏菌（乳牙）和纤细拟杆菌、腐蚀艾肯氏菌和具核梭杆菌（恒牙）。例2为9岁男童，分别为具核梭菌、中间梭菌、洛氏梭菌和腐蚀梭菌。病例2的血清显示对伴放线菌血清型B的特异性IgG抗体反应升高。因此，更广泛的物种比迄今报道的可能与Papillon-Lefevre综合征，包括放线菌伴放线菌和F核。
Microbiological and serological (enzyme linked immunosorbent assay) investigations were carried out, including karyotyping, on two Asian children with Papillon-Lefevre syndrome. In case 1, a girl aged four years, the most prevalent putative periodontopathogens were Eikenella corrodens, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia (deciduous dentition) and Bacteroides gracilis, E corrodens and F nucleatum (permanent dentition). In case 2, a boy aged nine years, they were F nucleatum, P intermedia and P loeschii and E corrodens. Serum from case 2 showed a raised specific IgG antibody response to Actinomyces actinomycetemcomitans serotype b. Thus, a wider range of species than hitherto reported may be associated with Papillon-Lefevre syndrome, including A actinomycetemcomitans and F nucleatum.