Quantitative and ultrastructural studies of excimer laser ablation of the cornea at 193 and 248 nanometers
Quantitative and ultrastructural studies of excimer laser ablation of the cornea at 193 and 248 nanometers
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193 和 248 纳米准分子激光角膜切削的定量和超微结构研究
DOI：
10.1002/lsm.1900070203
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发表时间：
1987
影响因子：
2.4
通讯作者：
R. Steinert
中科院分区：
文献类型：
--
作者：
C. Puliafito;K. Wong;R. Steinert
使用193 nm和248 nm的准分子激光辐射来产生去核小牛角膜的线性蚀刻穿孔。每个脉冲的蚀刻深度确定为各种曝光，并通过光和透射电子显微镜检查标本。与248 nm相比，发现193 nm的准分子激光烧蚀具有较低的烧蚀起始阈值，在增加的能量密度下每个脉冲的蚀刻深度增加较少，并且邻近角膜的结构改变较少。对于193 nm，结构变化极小，仅限于小于0.3 μm宽的区域，并且不随能量密度的增加而增加。这些研究表明，准分子激光屈光手术的临床策略将采用193 nm波长，根据手术策略选择能量密度。在193 nm处高于600 mJ/cm 2的烧蚀暴露可以给出最可重复的蚀刻深度。
Excimer laser radiation at 193 nm and 248 nm was used to create linear etch perforations of enucleated calf corneas. The etch depth per pulse was determined for various exposures, and specimens were examined by light and transmission electron microscopy. Compared to 248 nm, excimer laser ablation at 193 nm was found to have a lower threshold for onset of ablation, less increase in etch depth per pulse at increasing fluences, and less structural alteration in adjacent cornea. For 193 nm, structural alterations were minimal, confined to an area less than 0.3 μm wide, and did not increase with increasing fluence. These studies suggest that clinical strategies for excimer laser refractive surgery will employ the 193‐nm wavelength, with fluence chosen depending on surgical strategy. Ablation exposures above 600 mJ/cm2 at 193 nm may give the most repeatable etch depth.