Influence of a short-term iron-deficient diet on hepatic gene expression profiles in rats.
Influence of a short-term iron-deficient diet on hepatic gene expression profiles in rats.
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DOI：
10.1371/journal.pone.0065732
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Abe K
中科院分区：
文献类型：
--
作者：
Kamei A;Watanabe Y;Kondo K;Okada S;Shinozaki F;Ishijima T;Nakai Y;Kondo T;Arai S;Abe K
铁是人体必需的矿物质，缺铁通常会导致贫血。然而，由于非贫血性缺铁可能存在，我们对肝脏进行了全面的转录组分析，以确定这种情况对身体的影响。四周龄的雄性大鼠以低铁饮食(约3ppm铁)喂养3天，并与正常饮食(48ppm铁)的大鼠进行对照。缺铁饮食组大鼠出现非贫血型缺铁状态。DNA微阵列分析显示，在这短时间内，这种状态对肝脏的营养代谢产生了各种影响。与先前研究的长期(17天)缺铁数据相比，发现一些变化的基因在短期和长期缺铁模型中是共同的，一些是短期缺铁模型所特有的，另一些则是在两个饲养期之间相反的调控。综上所述，这些数据表明，尽管在非贫血性缺铁期间，血液中的血红蛋白水平本身保持不变，但参与维持能量平衡的各种代谢过程发生了变化。
Iron is an essential mineral for the body, and iron deficiency generally leads to anemia. However, because non-anemic iron deficiency can exist, we performed a comprehensive transcriptome analysis of the liver to define the effects of this condition on the body. Four-week-old male rats were fed a low-iron diet (approximately 3 ppm iron) for 3 days and compared with those fed a normal diet (48 ppm iron) by pair feeding as a control. The rats in the iron-deficient diet group developed a non-anemic iron-deficient state. DNA microarray analysis revealed that during this short time, this state conferred a variety of effects on nutrient metabolism in the liver. In comparison with long-term (17 days) iron-deficiency data from a previous study, some of the changed genes were found to be common to both short- and long-term iron deficiency models, some were specific to the short-term iron deficiency model, and the others were oppositely regulated between the two feeding terms. Taken together, these data suggest that although the blood hemoglobin level itself remains unchanged during non-anemic iron deficiency, a variety of metabolic processes involved in the maintenance of the energy balance are altered.
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影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
DOI：
10.1016/j.biocel.2004.02.007
发表时间：
2004-11-01
影响因子：
4
作者：
Aisen, P
通讯作者：
Aisen, P
DOI：
10.1152/ajpgi.00489.2004
发表时间：
2005-05-01
影响因子：
4.5
作者：
Collins, JF;Franck, CA;Ghishan, FK
通讯作者：
Ghishan, FK
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.1
作者：
Irizarry, RA;Hobbs, B;Speed, TP
通讯作者：
Speed, TP