Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
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DOI：
10.1126/science.283.5400.401
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发表时间：
1999-01-15
期刊：
影响因子：
56.9
通讯作者：
Parmentier, M
中科院分区：
文献类型：
--
作者：
Ledent, C;Valverde, O;Parmentier, M
中枢大麻素受体（CB 1）的功能进行了研究，通过其基因的无效。突变小鼠对大麻素类药物没有反应，证明了CB1受体在介导镇痛、强化、低温、低运动和低血压中的独特作用。阿片类药物的急性效应不受影响，但吗啡的强化特性和戒断综合征的严重程度大大降低。这些观察结果表明，CB1受体参与阿片类药物的动机特性和身体依赖性的发展，并扩展了CB1和阿片类药物受体在介导成瘾行为的大脑区域中的相互作用的概念。
The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension, The acute effects of opiates were unaffected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome were strongly reduced. These observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.