Evaluation of Circulating Tumor Cells in Predicting Therapeutic Response in Small Cell Lung Cancer Patients
Evaluation of Circulating Tumor Cells in Predicting Therapeutic Response in Small Cell Lung Cancer Patients
复制标题
评估循环肿瘤细胞预测小细胞肺癌患者的治疗反应
DOI：
10.1016/j.arcmed.2016.10.003
复制
发表时间：
2016-08-01
影响因子：
7.7
通讯作者：
Li, Wei
中科院分区：
文献类型：
--
作者：
Wang, Xu;Ma, Kewei;Li, Wei
背景和目标。循环肿瘤细胞（CTC）在转移性癌症患者中具有预后意义，但其在预测肿瘤治疗反应方面的效用尚不清楚。本研究旨在探讨CTCs与小细胞肺癌（SCLC）治疗反应的相关性。本研究对96例小细胞肺癌患者的临床和病理资料进行了评价。CellSearch试剂盒用于检测外周血样品中的CTC。采用Fisher精确检验和Mann-Whitney U检验进行统计学分析。在基线时，47例（50.0%）SCLC患者具有可检测的CTC计数。发现血清神经元特异性烯醇化酶（NSE）与CTC阈值相关。但是，无显著差异。观察任何阈值CTC计数与治疗反应、性别、年龄（60岁）、吸烟状态、抗利尿激素分泌不当综合征（SIADH）或Ki 67表达的相关性。SCLC患者中CTC的检测与血清NSE相关，但与癌症治疗反应无关。(C)2016年IMSS。爱思唯尔公司出版
Background and Aims. Circulating tumor cells (CTCs) have prognostic significance in patients with metastatic cancer, but their utility in predicting the response to tumor therapy is unknown. This study examined the correlation of CTCs with the therapeutic response in small cell lung cancer (SCLC).Methods. Clinical and pathological data from 96 SCLC patients were evaluated in this study. CellSearch kits were used to detect CTCs in peripheral blood samples. Statistical analysis was performed using Fisher exact test and Mann-Whitney U test.Results. At baseline, 47 (50.0%) SCLC patients had detectable CTC counts. Serum neuron-specific enolase (NSE) was found to be associated with CTC thresholds. However, no significant differences. were observed for an association of any threshold CTC count with the treatment response, with gender, age ( 60 years), smoking status, syndrome of inappropriate antidiuretic hormone (SIADH), or Ki67 expression.Conclusion. Detection of CTCs in SCLC patients was associated with serum NSE but not with response to cancer therapy. (C) 2016 IMSS. Published by Elsevier Inc.