Effects of electrical stimulation of the striatum on bladder activity in cats
Effects of electrical stimulation of the striatum on bladder activity in cats
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DOI：
10.1002/nau.20682
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发表时间：
2009-08
影响因子：
2
通讯作者：
Tatsuya Yamamoto;Ryuji Sakakibara;Ken Nakazawa;T. Uchiyama;Eiji Shimizu;Takamichi Hattori
中科院分区：
文献类型：
--
作者：
Tatsuya Yamamoto;Ryuji Sakakibara;Ken Nakazawa;T. Uchiyama;Eiji Shimizu;Takamichi Hattori
帕金森氏病(PD)影响黑质纹状体投射，导致排尿障碍。过度活跃的膀胱(OAB)症状，如尿急或尿失禁，在PD患者中很常见。多项尿动力学研究表明，逼尿肌过度活动可引起PD患者的OAB症状。我们认为纹状体功能障碍可能与PD患者逼尿肌过度活动的发病机制有关。然而，纹状体在膀胱收缩中的作用仍不清楚。
Parkinson's disease (PD) affects the nigrostriatal projections leading to micturition disturbance in most cases. Overactive bladder (OAB) symptoms such as urinary urgency or urgent urinary incontinence are common amongst PD patients. Several urodynamic studies have revealed that detrusor overactivity causes OAB symptoms in PD patients. We assert that striatal dysfunction might contribute to the pathogenesis of detrusor overactivity in PD patients. However, the role of the striatum in bladder contraction remains unclear.