The regulation of inflammation by interferons and their STATs.
The regulation of inflammation by interferons and their STATs.
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DOI：
10.4161/jkst.23820
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Decker T
中科院分区：
文献类型：
--
作者：
Rauch I;Müller M;Decker T
干扰素 (IFN) 细分为 I 型 IFN（IFN-I，此处与 IFN-α/β 同义）、II 型 (IFN-γ) 和 III 型 IFN (IFN-III/IFN-λ)，它们通过形成 STAT1 二聚体（主要是 IFN-γ）或 ISGF3 复合物（一种 STAT1-STAT2-IRF9 异三聚体），通过 STAT 1 和 2 重新编程核基因表达 （干扰素-I 和干扰素-III）。免疫系统中干扰素的主要活性是保护细胞免受病毒复制并激活巨噬细胞以增强效应功能。然而，IFN 及其 STAT 对免疫系统的影响远远超出了这些活动，还包括炎症的控制。本综述的目的是概述炎症过程的不同方面，显示 IFN/STAT 的调节输入。
Interferons (IFN) are subdivided into type I IFN (IFN-I, here synonymous with IFN-α/β), type II (IFN-γ) and type III IFN (IFN-III/IFN-λ) that reprogram nuclear gene expression through STATs 1 and 2 by forming STAT1 dimers (mainly IFN-γ) or the ISGF3 complex, a STAT1-STAT2-IRF9 heterotrimer (IFN-I and IFN-III). Dominant IFN activities in the immune system are to protect cells from viral replication and to activate macrophages for enhanced effector function. However, the impact of IFN and their STATs on the immune system stretches far beyond these activities and includes the control of inflammation. The goal of this review is to give an overview of the different facets of the inflammatory process that show regulatory input by IFN/STAT.