IMMUNOMODULATION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS - A MODEL OF TOLERANCE INDUCTION WITH RETINAL ANTIGEN
IMMUNOMODULATION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS - A MODEL OF TOLERANCE INDUCTION WITH RETINAL ANTIGEN
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DOI：
10.1038/eye.1994.10
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发表时间：
1994-01-01
期刊：
影响因子：
3.9
通讯作者：
FORRESTER, JV
中科院分区：
文献类型：
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作者：
DICK, AD;CHENG, YF;FORRESTER, JV
实验性自身免疫性葡萄膜视网膜炎(EAU)是一种由CD4+T淋巴细胞介导的葡萄膜和视网膜炎症。作为人类后葡萄膜炎的模型，它可以进一步了解葡萄膜炎的潜在免疫发病机制。它还允许对免疫抑制疗法进行临床前试验，并在体内评估免疫干预的替代策略。本文着重介绍了预防免疫反应启动或持续的可能的免疫策略方式，特别是关于在视网膜抗原免疫前鼻腔诱导视网膜抗原耐受的新效果的报道。讨论了这种天然的免疫抑制方法在治疗自身免疫性疾病中的机制和潜在的应用。
Experimental autoimmune uveoretinitis (EAU) is a CD4+ T-lymphocyte mediated inflammation of the uveal tract and retina. As a model of human posterior uveitis it permits further understanding of the underlying immunopathogenesis of uveitis. It also allows for preclinical trials of immunosuppressive therapies and in vivo assessment of alternative strategies for immunointervention. This review highlights possible immunostrategic modalities which prevent the initiation or perpetuation of the immune response, and in particular reports on the novel effect of intranasal induction of tolerance with retinal antigens, prior to immunisation with retinal antigens. The mechanisms and potential application of this 'natural' method of immunosuppression in the treatment of autoimmune disease are discussed.