The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress
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DOI：
10.1016/j.jalz.2012.09.012
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发表时间：
2013-11-01
影响因子：
14
通讯作者：
Soininen, Hilkka
中科院分区：
文献类型：
--
作者：
Kivipelto, Miia;Solomon, Alina;Soininen, Hilkka
背景：芬兰预防认知障碍和残疾的老年干预研究 (FINGER) 是一项在芬兰正在进行的多中心、随机、对照试验。材料：参与者（1200 名有认知能力下降风险的个体）是从之前基于人群的非干预研究中招募的。纳入标准是 CAIDE 痴呆风险评分 >= 6，并且认知表现处于平均水平或略低于年龄预期（但不是实质性损伤），这是由建立阿尔茨海默病登记协会 (CERAD) 神经心理电池组评估的。为期 2 年的多领域干预包括： 营养指导；锻炼;认知训练和社交活动；以及代谢和血管危险因素的管理。对照组的人定期接受健康建议。主要结果是通过改良的神经心理学测试电池、斯特鲁普测试和越野测试来测量的认知表现。主要的次要结局是： 痴呆（长期随访后）；残疾；抑郁症状；血管危险因素和结果；生活质量；卫生资源的利用；结果：筛查于 2009 年 9 月开始，于 2011 年 12 月完成。所有 1200 人均已入组，干预措施正在按计划进行。基线临床特征表明存在多种血管危险因素和不健康生活方式相关因素，为预防创造了机会之窗。干预措施将于 2014 年完成。结论：FINGER 处于国际合作努力的前沿，旨在解决早期识别晚年认知障碍风险增加的个体的临床和公共卫生问题，并制定预防或延缓认知障碍和痴呆症发作的干预策略。 (C) 2013 年阿尔茨海默病协会。版权所有。
Background: Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a multi-center, randomized, controlled trial ongoing in Finland.Materials: Participants (1200 individuals at risk of cognitive decline) are recruited from previous population-based non-intervention studies. Inclusion criteria are CAIDE Dementia Risk Score >= 6 and cognitive performance at the mean level or slightly lower than expected for age (but not substantial impairment) assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery. The 2-year multidomain intervention consists of: nutritional guidance; exercise; cognitive training and social activity; and management of metabolic and vascular risk factors. Persons in the control group receive regular health advice. The primary outcome is cognitive performance as measured by the modified Neuropsychological Test Battery, Stroop test, and Trail Making Test. Main secondary outcomes are: dementia (after extended follow-up); disability; depressive symptoms; vascular risk factors and outcomes; quality of life; utilization of health resources; and neuroimaging measures.Results: Screening began in September 2009 and was completed in December 2011. All 1200 persons are enrolled and the intervention is ongoing as planned. Baseline clinical characteristics indicate that several vascular risk factors and unhealthy lifestyle related factors are present, creating a window of opportunity for prevention. The intervention will be completed during 2014.Conclusions: The FINGER is at the forefront of international collaborative efforts to solve the clinical and public health problems of early identification of individuals at increased risk of late-life cognitive impairment, and of developing intervention strategies to prevent or delay the onset of cognitive impairment and dementia. (C) 2013 The Alzheimer's Association. All rights reserved.