Costs and benefits of two doses of fluphenazine.
Costs and benefits of two doses of fluphenazine.
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两剂氟奋乃静的成本和效益。
DOI：
10.1001/archpsyc.1983.01790220015002
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发表时间：
1984
影响因子：
--
通讯作者：
Philip R. A. May
中科院分区：
文献类型：
--
作者：
Stephen R. Marder;T. Putten;Jim Mintz;J. Mckenzie;M. Lebell;G. Faltico;Philip R. A. May
在双盲比较中评价了低剂量和常规剂量抗精神病药物维持治疗的相对成本和效益，每两周给予5和25 mg氟奋乃静癸酸酯。受试者为50名符合精神分裂症DSM-III标准的患者，他们成功地维持了25 mg或更少的氟奋乃静癸酸酯。一年生存分析显示，两种剂量在预防复发方面没有统计学显著差异。接受较高剂量的患者似乎感觉更不舒服，如霍普金斯症状自评量表-90的子量表评分较高所示。此外，接受较高剂量的患者具有较高的副作用评分。这些发现表明，目前每两周维持25 mg或更少的氟奋乃静癸酸酯的相当大比例的患者将与少至5 mg一样好。
The relative costs and benefits of low- and conventional-dose neuroleptic maintenance therapy were evaluated in a double-blind comparison of 5 and 25 mg of fluphenazine decanoate administered every two weeks. Subjects were 50 patients fulfilling DSM-III criteria for schizophrenic disorder who had been successfully maintained with 25 mg or less of fluphenazine decanoate. A one-year survival analysis disclosed that there were no statistically significant differences between the two doses insofar as preventing relapse. Patients receiving the higher dose appeared to feel more uncomfortable, as indicated by higher scores on subscales of the Hopkins Symptom Checklist-90. In addition, patients receiving the higher dose had higher side-effect scores. These findings suggest that a substantial proportion of patients who are presently maintained with 25 mg or less of fluphenazine decanoate every two weeks will do just as well with as little as 5 mg.