Plasma β-Endorphin, Corticotrophin and Growth Hormone Responses to Exercise in Pubertal and Prepubertal Children
Plasma β-Endorphin, Corticotrophin and Growth Hormone Responses to Exercise in Pubertal and Prepubertal Children
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青春期和青春期前儿童血浆 β-内啡肽、促肾上腺皮质激素和生长激素对运动的反应
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发表时间：
1994
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通讯作者：
A. Orsetti
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作者：
O. Bouix;J. Brun;C. Fédou;E. Raynaud;B. Kerdelhué;V. Lenoir;A. Orsetti
一些研究者报告了成年男性和女性在运动期间血浆β-内啡肽浓度的增加。然而，很少有人知道这种生理激素对儿童运动的反应。在这项研究中，我们调查了血浆β-内啡肽，促肾上腺皮质激素和生长激素对运动的40名青春期前和青春期儿童。受试者是作为出现生长迟缓的儿童和青少年人群的一部分招募的，并根据不存在任何内分泌或代谢疾病的临床或生物学体征进行选择。有16名女孩和24名男孩，其中24名处于青春期前，16名处于青春期。使用标准化的15分钟回旋运动计工作量，逐渐增加儿童的心率，达到理论最大值的90%。运动导致血浆β-内啡肽（平均值+/- SEM）（4.26 +/- 0.47 vs 5.74 +/- 0.56 fmol/ml）、ACTH（3.71 +/- 0.41 vs 6.2 +/- 0.62 fmol/ml）和GH（147 +/- 29 vs 364 +/- 67 fmol/ml）显著增加（p < 0.01）。对于这三种激素中的每一种，对运动有显著激素反应的儿童的百分比约为75%，但在研究的40名儿童中，只有3名儿童对运动没有任何激素反应。运动诱导的血浆β-内啡肽和ACTH的增加显著相关（p < 0.01）。相比之下，GH和β-内啡肽或ACTH值之间没有显着关系。此外，尽管青春期儿童运动诱导的血浆GH升高显著高于青春期前儿童（p < 0.001），但两组相应的β-内啡肽和ACTH水平非常相似。（250字处删节）
An increase in plasma beta-endorphin concentrations during exercise has been reported in adult men and women by several investigators. However, very little is known about this physiological hormonal response to exercise in children. In this study, we investigated plasma beta-endorphin, ACTH and GH responses to exercise in 40 prepubertal and pubertal children. Subjects were recruited as part of a population of children and adolescents presenting growth retardation and were selected on the basis of the absence of any clinical or biological signs of endocrine or metabolic disease. There were 16 girls and 24 boys with 24 prepubertal and 16 pubertal individuals. A standardised 15 min workload on cycloergometer was used to progressively increase the heart rate of the children up to 90% of the theoretical maximal value. Exercise resulted in a significant increase (p < 0.01) in plasma beta-endorphin (mean +/- SEM) (4.26 +/- 0.47 vs 5.74 +/- 0.56 fmol/ml), ACTH (3.71 +/- 0.41 vs 6.2 +/- 0.62 fmol/ml) and GH (147 +/- 29 vs 364 +/- 67 fmol/ml). The percentage of children with significant hormonal response to exercise was about 75% for each of the 3 hormones but only 3 of the 40 children studied did not show any hormonal response to exercise. Exercise-induced increases in plasma beta-endorphin and ACTH were significantly correlated (p < 0.01). By contrast, there was no significant relationship between GH and beta-endorphin or ACTH values. Furthermore, whereas exercise-induced plasma GH increase was significantly higher in pubertal than in prepubertal children (p < 0.001), corresponding beta-endorphin and ACTH levels were quite similar in the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)