CHOLECYSTECTOMY AND RIGHT-SIDED COLON CANCER: AN EPIDEMIOLOGICAL STUDY
CHOLECYSTECTOMY AND RIGHT-SIDED COLON CANCER: AN EPIDEMIOLOGICAL STUDY
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胆囊切除术和右侧结肠癌：流行病学研究
DOI：
10.1016/s0140-6736(81)90830-8
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
L. Kuller
中科院分区：
文献类型：
--
作者：
L. Vernick;L. Kuller
在一项病例对照研究中，对150例经组织学证实的盲肠或升结肠腺癌患者和两个对照组进行了既往胆囊切除术与右半结肠癌之间的关系进行了研究。一个对照组包括150名患者，年龄，性别和种族相匹配，组织学证实为降结肠或乙状结肠腺癌，另一个对照组为123名邻居对照。与左侧结肠癌对照组相比，右侧结肠癌病例胆囊切除术后患结肠癌的相对危险度为1.87。与健康对照组比较，相对危险度为1·86。与两个对照组相比，相对危险度为1.77，95%置信限为0.95和3.3（p = 0.07）。胆囊切除术后右半结肠癌风险增加可能与胆囊切除后胆汁代谢的变化有关。
The relation between prior cholecystectomy and right-sided colon cancer was investigated in a case-control study of 150 patients with histologically confirmed adenocarcinoma of the caecum or ascending colon and of two comparison groups. One comparison group consisted of 150 patients, matched for age, sex, and race, who had histologically confirmed adenocarcinoma of the descending or sigmoid colon and the other of 123 neighbourhood controls. Compared with left-sided cancer controls, the right-sided colon cancer cases had a relative risk of 1·87 for colon cancer after cholecystectomy. The relative risk was 1·86 when they were compared with the neighourhood controls. When compared with both control groups relative risk was 1·77, with 95% confidence limits of 0·95 and 3·3 (p = 0·07). The increased risk of right-sided colon cancer after cholecystectomy may be associated with changes in biliary metabolism occurring after removal of a gall bladder.