Epithelial stem cells: the eye provides a vision
Epithelial stem cells: the eye provides a vision
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DOI：
10.1038/sj.eye.6700575
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发表时间：
2003-11-01
期刊：
影响因子：
3.9
通讯作者：
Sun, TT
中科院分区：
文献类型：
--
作者：
Lavker, RM;Sun, TT
上皮干细胞在组织动态平衡、伤口修复和癌变中起着核心作用。角膜上皮干细胞已被证实存在于角膜缘上皮，而结膜穹隆带似乎是结膜上皮干细胞的主要部位。角膜和结膜上皮以及毛囊和毛囊间表皮的干细胞具有共同的重要特征：它们能够自我更新；它们相对静止(慢周期)；它们可以被诱导增殖；它们是多能的。很明显，角膜和毛囊角质形成细胞之间存在一定程度的弹性。
Epithelial stem cells play a central role in tissue homeostasis, wound repair, and carcinogenesis. Corneal epithelial stem cells have been demonstrated to reside in the limbal epithelium, while the fornical zone of the conjunctiva appears to be a predominant site of conjunctival epithelial stem cells. Stem cells of the corneal and conjunctival epithelia, as well as the hair follicle and interfollicular epidermis share important features: they are capable of self renewal; they are relatively quiescent (slow-cycling); they can be induced to proliferate; and they are multipotent. Its becoming apparent that a certain degree of flexibility exists between corneal and hair follicle keratinocytes.