Probable RBD and Association With Neurodegenerative Disease Markers: A Population-Based Study
Probable RBD and Association With Neurodegenerative Disease Markers: A Population-Based Study
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DOI：
10.1002/mds.26350
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发表时间：
2015-09-01
影响因子：
8.6
通讯作者：
Hoegl, Birgit
中科院分区：
文献类型：
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作者：
Mahlknecht, Philipp;Seppi, Klaus;Hoegl, Birgit
工作背景：快速眼动睡眠行为障碍（RBD）的患病率及其与一般人群中神经退行性疾病标志物的相关性尚不清楚。研究方法：我们通过两个有效的问卷，RBD筛查问卷（RBDSQ）和因斯布鲁克RBD量表（RBD-I），评估了可能的RBD的患病率，并在Bruneck研究队列中研究了其与60岁或以上神经退行性疾病的临床和影像学标志物的相关性。结果：在456名无帕金森病的参与者中，4.6%（RBDSQ; 95%CI，3.0%-7.0%）和7.7%（RBD-I; 95%CI，5.6%-10.5%）可能患有RBD。用任何一种问卷诊断的可能的RBD与嗅觉减退（趋势; P < 0.1），焦虑（P < 0.05），抑郁（P <0.05），抗抑郁药使用（P < 0.05）和自我报告的非运动症状（P < 0.01）相关，特别是，唾液滴落，记忆问题，冷漠，注意力问题和焦虑。结论：我们的研究结果可能为未来的研究提供了基础，旨在通过筛查一般老年人群的RBD来确定路易体病的风险队列。(c)2015年国际帕金森和运动障碍协会
Background: The prevalence of rapid eye movement sleep behavior disorder (RBD) and its association with markers of neurodegeneration in the general population are poorly defined. Methods: We assessed the prevalence of probable RBD defined by two validated questionnaires, the RBD Screening Questionnaire (RBDSQ) and the Innsbruck RBD-Inventory (RBD-I), and studied its associations with clinical and imaging markers for neurodegeneration in the Bruneck Study cohort aged 60 y or older. Results: Of the 456 participants without Parkinson's disease, 4.6% (RBDSQ; 95% CI, 3.0%-7.0%) and 7.7% (RBD-I; 95% CI, 5.6%-10.5%) had probable RBD. Probable RBD diagnosed with either of the questionnaires was associated with hyposmia (trend; P < 0.1), anxiety (P < 0.05), depression (P < 0.05), antidepressant use (P < 0.05), and self-reported non-motor symptoms (P < 0.01), specifically, dribbling saliva, memory problems, apathy, concentration problems, and anxiety. Conclusions: Our findings may provide a basis for future studies intending to identify cohorts at risk for Lewy body diseases through screening of the general elderly population for RBD. (c) 2015 International Parkinson and Movement Disorder Society