Gasdermin-d played a critical role in the cyclic stretch-induced inflammatory reaction in human periodontal ligament cells.
Gasdermin-d played a critical role in the cyclic stretch-induced inflammatory reaction in human periodontal ligament cells.
复制标题
Gasdermin-d 在人牙周膜细胞周期性拉伸诱导的炎症反应中发挥着关键作用。
DOI：
10.1007/s10753-018-0912-6
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发表时间：
2018
期刊：
影响因子：
5.1
通讯作者：
Xu C
中科院分区：
文献类型：
--
作者：
Zhuang J;Wang Y;Qu F;Wu Y;Zhao D;Xu C
AbstractIt has been shown that cyclic stretch could induce inflammatory response such as pyroptosis and the release of IL-1β in human periodontal ligament cells, through activating inflammasome and related caspases. Though gasdermin-d (GSDMD) has been reported to be present in some inflammatory diseases and function as a crucial executioner of pyroptosis, the role of GSDMD in the stretch-induced inflammatory response in human periodontal ligament cells (HPDLCs) has not been well clarified. In this study, it was found that GSDMD was activated by cyclic stretch, and its activation affected the pyroptotic rate in HPDLCs, leading to the maturation and secretion of IL-1β and IL-18 ultimately. In addition, GSDMD was found to be regulated by caspase-1 directly. Nevertheless, the exact relationship between inflammasomes and GSDMD in the stretch-induced inflammatory response still needs to be further elucidated.
