Highly elevated serum concentrations of perfluoroalkyl substances in fishery employees from Tangxun Lake, China
Highly elevated serum concentrations of perfluoroalkyl substances in fishery employees from Tangxun Lake, China
复制标题
中国汤逊湖渔业从业人员血清全氟烷基物质浓度显着升高
DOI：
10.1021/es4057467
复制
发表时间：
2014
影响因子：
11.4
通讯作者：
Cai Yaqi
中科院分区：
文献类型：
--
作者：
Zhou Zhen;Shi Yali;Vestergren Robin;Wang Thanh;Liang Yong;Cai Yaqi
据报告，中国的全氟烷基和多氟烷基物质（PFAS）的生产和使用不断增加，一些研究表明，中国有一些亚群体高度接触这些化学品，而且接触程度不断增加。本文对汤逊湖渔业从业人员PFASs的暴露水平进行了综合评价。与同一城市的参照组（n= 9，全氟辛烷磺酸中位数为18.7纳克/毫升）相比，渔业雇员（n= 39，全氟辛烷磺酸中位数为10 400纳克/毫升）的血清中C4至C12全氟辛烷磺酸浓度异常高。在比较不同暴露途径的基础上，得出汤逊湖污染鱼是渔业从业人员PFAS的主要暴露源，血清PFAS浓度与从业时间呈正相关。渔业雇员体内的全氟辛烷磺酸异构体分布显示，线性全氟辛烷磺酸的比例（78.4%）明显高于背景暴露参照组（66.8%），反映出湖泊鱼类的全氟辛烷磺酸异构体分布高度线性（>90%）。C4-C10全氟烷基羧酸（PFCAs）和全氟烷基磺酸（PFSA）的中位肾脏清除率（CL肾）范围分别为0.020 - 16.5 mL/天/kg和0.013 - 9.43 mL/天/kg。全氟烷基碳少于8的全氟乙酸主要通过尿液消除，而其他排泄途径可能有助于消除长链全氟乙酸和全氟水杨酸。计算得出的渔业雇员每日全氟辛烷磺酸接触量大大超过每日可耐受摄入量限值，但临床血液化学参数大多在正常参考范围内。然而，需要更多的流行病学研究来解决汤逊湖地区PFAS暴露与健康影响之间的潜在关联。
Increasing production and use of per- and polyfluoroalkyl substances (PFASs) has been reported from China, and a few studies have shown there are subpopulations in China with high and increasing exposure to these chemicals. In this paper, we present a comprehensive exposure assessment of PFASs in fishery employees from Tangxun Lake, China. Exceptionally high serum concentrations of C4 to C12 PFASs were observed in fishery employees (n= 39, median perfluorooctanesulfonic acid (PFOS) 10 400 ng/mL) compared to a reference group from the same city (n= 9, median PFOS 18.7 ng/mL). On the basis of the comparison of different exposure pathways, it was concluded that contaminated fish from Tangxun Lake was the primary source of PFAS exposure to fishery employees, and there was a positive association between serum PFAS concentrations and time of employment in the fishery. PFOS isomer profiles in fishery employees showed a significantly higher proportion of linear PFOS (78.4%) compared to the background-exposed reference group (66.8%), reflecting the highly linear PFOS isomer profile (>90%) of lake fish. Median renal clearance rates (CLrenal) of C4 to C10 perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkanesulfonic acids (PFSAs) ranged from 0.020 to 16.5 mL/day/kg and 0.013 to 9.43 mL/day/kg, respectively. PFCAs with less than eight perfluoroalkyl carbons were primarily eliminated via urine, whereas other routes of excretion may have contributed to the elimination for long-chain PFCAs and PFSAs. Calculated daily PFOS exposures of fishery employees significantly exceeded tolerable daily intake limits, but clinical blood chemistry parameters were mostly within normal reference ranges. However, additional epidemiological studies are needed to address potential associations between PFAS exposure and health effects in the Tangxun Lake area.