Cardioprotective Effect of Sasanquasaponin Preconditioning via Bradykinin-NO Pathway in Isolated Rat Heart
Cardioprotective Effect of Sasanquasaponin Preconditioning via Bradykinin-NO Pathway in Isolated Rat Heart
复制标题
水茶皂甙通过缓激肽-NO途径预处理对离体大鼠心脏的心脏保护作用
DOI：
10.1002/ptr.2767
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发表时间：
2009-08-01
影响因子：
7.2
通讯作者：
He, Ming
中科院分区：
文献类型：
--
作者：
Liao, Zhangping;Yin, Dong;He, Ming
油茶皂苷（SQS）是油茶的有效成分。本研究旨在探讨SQS对离体大鼠心脏缺血再灌注（I/R）损伤的心脏保护作用及其可能机制。这些心脏在不同组中仅接受SQS或SQS和HOE140预处理，然后进行I/R损伤。测量血流动力学参数、氧化损伤和一氧化氮水平。结果表明，SQS预处理可以降低心律失常的发生率，改善心功能。此外，SQS 预处理可以保护离体 I/R 损伤的心脏免受脂质过氧化，这一点可以通过 SOD 和 GSH-Px 活性的增加以及 MDA 含量和 ROS 生成的减少来证明。然而，HOE140治疗逆转了所有这些指标。用 HOE140 处理后，NO 产生显着减少。因此我们可以推测SQS预处理可以诱导心脏保护作用，其可能的机制是SQS预处理激活缓激肽-NO系统对离体心脏中ROS的产生具有抑制作用。版权所有 (C) 2009 John Wiley & Sons, Ltd.
Sasanquasaponin (SQS) is an effective component of Camellia oleifera Abel This study was designed to investigate the cardioprotective effect of SQS against ischemia-reperfusion (I/R) injury and the possible mechanism in isolated rat hearts. These hearts were pretreated by SQS only or SQS and HOE140 in different groups, and then subjected to I/R injury. Hemodynamic parameters, oxidative injury, and NO level were measured. The results showed that SQS preconditioning could decrease the incidences of arrhythmias and improve the heart functions. In addition, SQS preconditioning could protect isolated I/R injured heart against lipid peroxidation, as evidenced by increases in SOD and GSH-Px activity, and by decreases in contents of MDA, ROS generation. However, HOE140 treatment reversed all these indexes. NO production was significantly decreased after a treatment with HOE140. So we can propose that SQS preconditioning could induce the cardioprotective effects and the possible mechanism was that the activation of bradykinin-NO system by SQS preconditioning had an inhibition effect on ROS generation in isolated heart. Copyright (C) 2009 John Wiley & Sons, Ltd.