Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood
Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood
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DOI：
10.1172/jci26690
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发表时间：
2005-10-01
影响因子：
15.9
通讯作者：
Sugarman, J
中科院分区：
文献类型：
--
作者：
Kurtzberg, J;Lyerly, AD;Sugarman, J
自1988年首次成功移植脐带血以来，脐带血已成为治疗血液和遗传疾病的造血干细胞和祖细胞的重要来源。在取得重大进展的同时，科学家、伦理学家和卫生政策制定者也面临着挑战。随着人们最近认识到需要建立一个收集、储存、分配和使用脐带血的国家系统，以及越来越多地关注脐带血作为胚胎的替代品作为再生医学的组织来源，脐带血引起了人们的极大关注。我们回顾了脐带血库和移植的发展，然后讨论了科学和伦理问题，影响了脐带血采集，库和使用的既定和研究实践。
Since the first successful transplantation of umbilical cord blood in 1988, cord blood has become an important source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Significant progress has been accompanied by challenges for scientists, ethicists, and health policy makers. With the recent recognition of the need for a national system for the collection, banking, distribution, and use of cord blood and the increasing focus on cord blood as an alternative to embryos as a source of tissue for regenerative medicine, cord blood has garnered significant attention. We review the development of cord blood banking and transplantation and then discuss the scientific and ethical issues influencing both established and investigational practices surrounding cord blood collection, banking, and use.