Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1
Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1
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DOI：
10.1038/s41429-019-0234-4
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发表时间：
2019-12-01
影响因子：
3.3
通讯作者：
Maeda, Ken
中科院分区：
文献类型：
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作者：
Kuroda, Yudai;Yamagata, Haruka;Maeda, Ken
Feline herpesvirus type 1 (FHV-1) causes a potentially fatal disease in cats. Through the use of virus inhibition and cytotoxicity assays, sinefungin, a nucleoside antibiotic, was assessed for its potential to inhibit the growth of FHV-1. Sinefungin inhibited in vitro growth of FHV-1 most significantly over other animal viruses, such as feline infectious peritonitis virus, equine herpesvirus, pseudorabies virus and feline calicivirus. Our results revealed that sinefungin specifically suppressed the replication of FHV-1 after its adsorption to the host feline kidney cells in a dose-dependent manner without obvious cytotoxicity to the host cells. This antibiotic can potentially offer a highly effective treatment for animals infected with FHV-1, providing alternative medication to currently available antiviral therapies.
