Neural responses to pup calls and pup odors in California mouse fathers and virgin males
Neural responses to pup calls and pup odors in California mouse fathers and virgin males
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DOI：
10.1016/j.bbr.2022.114024
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发表时间：
2022-07
影响因子：
2.7
通讯作者：
Kerianne M. Wilson;April M. Arquilla;Kelsey M. Rosales-Torres;Manal T. Hussein;May G. Chan;K. Razak
中科院分区：
文献类型：
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作者：
Kerianne M. Wilson;April M. Arquilla;Kelsey M. Rosales-Torres;Manal T. Hussein;May G. Chan;K. Razak
哺乳动物母性护理的发生与婴儿相关感觉刺激的神经加工可塑性有关；然而，我们对感觉可塑性与父亲身份的关系知之甚少。我们量化了双亲本加利福尼亚小鼠（Peromyscus californicus）幼年不熟悉的幼崽对未交配雄鼠和新父亲的嗅觉和听觉刺激的行为和神经反应。每只雄性被暴露在四种化学感觉刺激（狗狗有气味或没有气味的棉花[对照组]）和听觉刺激（狗狗的叫声或白噪音[对照组]）中的一种下10分钟。父亲和处女在接触感官刺激或随后的一小时内的行为没有差异；然而，与对照刺激相比，两组的雄性在暴露于与幼崽相关的刺激期间和之后都更加活跃。雄鼠主嗅球（MOB）中Fos的表达量较低，而视前内侧区（MPOA）和终纹内分腹侧床核（STMV）中Fos的表达量较处女高。最后，与对照刺激相比，当暴露于小狗气味时，雄性在MPOA中的Fos表达更高，当暴露于小狗气味和小狗叫声时，与只听到小狗叫声或对照刺激相比，雄性在MPOA中表达更高。这些结果表明，幼崽的气味和发声对雄性的行为和MPOA的激活具有附加或协同作用。
The onset of mammalian maternal care is associated with plasticity in neural processing of infant-related sensory stimuli; however, little is known about sensory plasticity associated with fatherhood. We quantified behavioral and neural responses of virgin males and new fathers to olfactory and auditory stimuli from young, unfamiliar pups in the biparental California mouse (Peromyscus californicus). Each male was exposed for 10 min to one of four combinations of a chemosensory stimulus (pup-scented or unscented cotton [control]) and an auditory stimulus (pup vocalizations or white noise [control]). Behavior did not differ between fathers and virgins during exposure to sensory stimuli or during the following hour; however, males in both groups were more active both during and after exposure to pup-related stimuli compared to control stimuli. Fathers had lower expression of Fos in the main olfactory bulbs (MOB) but higher expression in the medial preoptic area (MPOA) and bed nucleus of the stria terminalis medial division, ventral part (STMV) compared to virgins. Lastly, males had higher Fos expression in MPOA when exposed to pup odor compared to control stimuli, and when exposed to pup odor and pup calls compared to pup calls only or control stimuli. These findings suggest that the onset of fatherhood alters activity of MOB, MPOA and STMV and that pup odors and vocalizations have additive or synergistic effects on males’ behavior and MPOA activation.