Mitochondrial DNA mutations and aging
Mitochondrial DNA mutations and aging
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DOI：
10.1196/annals.1395.024
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Turnbull, Douglass M.
中科院分区：
文献类型：
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作者：
Krishnan, Kim J.;Greaves, Laura C.;Turnbull, Douglass M.
线粒体已被假设在衰老和神经退行性疾病如帕金森病（PD）和阿尔茨海默病中起作用。许多研究表明，线粒体DNA（mtDNA）突变在有丝分裂后组织中的积累，最近的数据表明，这也是衰老的有丝分裂组织的一个特征。这些数据中的大部分都是相关的，直到最近，随着聚合酶γ缺陷小鼠的发展，这些小鼠积累了高水平的mtDNA突变并显示出早衰表型，已经提出了一个更重要的致病作用。本文重点介绍了衰老研究的最新进展，即mtDNA突变在衰老过程中所起的作用。
Mitochondria have been hypothesized to play a role in both aging and neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease. Many studies have shown the accumulation of mitochondrial DNA (mtDNA) mutations in post-mitotic tissues and more recent data have shown this also to be a feature of aging mitotic tissues. Much of this data has been correlative, until recently with the development of polymerase gamma deficient mice which accumulate high levels of mtDNA mutations and show a premature aging phenotype, that a more causative role has been proposed. This article focuses on recent developments in aging research into the role that mtDNA mutations play in the aging process.