Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children
Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children
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DOI：
10.1016/j.biopsych.2005.03.032
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发表时间：
2005-08-01
影响因子：
10.6
通讯作者：
Glover, V
中科院分区：
文献类型：
--
作者：
O'Connor, TG;Ben-Shlomo, Y;Glover, V
背景资料：动物研究表明，产前应激与下丘脑-垂体-肾上腺（HPA）轴功能的长期紊乱有关，但缺乏人类的证据。本研究探讨了产前焦虑和10岁时昼夜皮质醇测量值之间的长期关联。在雅芳父母和儿童纵向研究的10岁儿童样本（n = 74）中，连续3天在觉醒时、觉醒后30分钟、下午4点和晚上9点收集皮质醇测量值，一项前瞻性纵向队列研究的母亲和儿童的焦虑和抑郁的措施，收集在怀孕和产后期间。分析检查产前焦虑的症状和皮质醇的多个指标之间的联系，HPA轴functioning.Results的指数：产前焦虑是显着相关的觉醒和下午皮质醇的个体差异后，占产科和社会人口风险（偏相关系数为0.32和0.25，p <0.05）。在控制了母亲焦虑和抑郁的多重产后评估后，唤醒皮质醇的效果仍然显着。这项研究提供了第一个人类证据，产前焦虑可能对儿童HPA轴功能产生持久影响，产前焦虑可能构成儿童和青少年精神病理学易感性增加的机制。
Background: Animal studies suggest that prenatal stress is associated with long-term disturbance in hypothalamic-pituitary-adrenal (HPA) axis function, but evidence in humans is lacking. This study examined the long-term association between prenatal anxiety and measures of diurnal cortisol at age 10 years.Methods: Measures of cortisol were collected at awakening, 30 min after awakening, and at 4 Pm and 9 PM on 3 consecutive days in a sample of 10-year-olds (n = 74) from the Avon Longitudinal Study of Parents and Children, a prospective longitudinal cohort study of mothers and children on whom measures of anxiety and depression were collected in pregnancy and the postpartum period. Analyses examined the links between symptoms of prenatal anxiety and multiple indicators of cortisol, an index of HPA axis functioning.Results: Prenatal anxiety was significantly associated with individual differences in awakening and afternoon cortisol after accounting for obstetric and sociodemographic risk (partial correlations were .32 and .25, p < .05). The effect for awakening cortisol remained significant after controlling for multiple postnatal assessments of maternal anxiety and depression.Conclusions. This study provides the first human evidence that prenatal anxiety might have lasting effects on HPA axis functioning in the child and that prenatal anxiety might constitute a mechanism for an increased vulnerability to psychopathology in children and adolescents.