Effect of two doses of botulinum toxin type A on maximum plantar contact area in hemiplegic stroke patients with pes equinovarus
Effect of two doses of botulinum toxin type A on maximum plantar contact area in hemiplegic stroke patients with pes equinovarus
复制标题
两种剂量A型肉毒毒素对脑卒中偏瘫马蹄内翻患者足底最大接触面积的影响
DOI：
10.11336/jjcrs.11.85
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yuriko Inoue
中科院分区：
文献类型：
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作者：
Yoshitaka Wada; Naruhito Otsuka;Nobuyuki Kawate;Hiroshi Moriyama;Hiromitsu Ezure;Yuriko Inoue
黄文忠，陈文忠.两种剂量A型肉毒毒素对脑卒中马蹄内翻足患者最大足底接触面积的影响。Jpn J Compr Rehabil Sci 2020; 11：85 - 90.目的：定量证明两种剂量的A型肉毒杆菌毒素（BoNT-A）对偏瘫患者马蹄内翻足的治疗效果。方法：本研究的受试者包括8名接受两种剂量BoNT-A的慢性脑卒中患者（平均给药间隔：136.0（10.5）天），并进行了片状负重下肢试验。在BoNT-A给药前和第一次和第二次给药后4周，测量瘫痪侧的最大足底接触面积、瘫痪侧和非瘫痪侧的最大足底接触面积比和改良Ashworth量表（MAS）。结果如下：与第一次给药相比，第二次给药后在瘫痪侧观察到最大足底接触面积显著增加。此外，与BoNT-A施用前相比，在施用第一剂量和第二剂量后，观察到瘫痪/非瘫痪最大足底接触面积的比率显著增加。MAS被观察到显着下降后，第一次和第二次剂量的管理相比，之前的BoNT-A administration.Conclusions：我们建议，足底接触面积的比较是有用的评估的治疗效果BoNT-A剂量对马蹄内翻足偏瘫中风患者。
Wada Y, Otsuka N, Kawate N, Moriyama H, Ezure H, Inoue Y. Effect of two doses of botulinum toxin type A on maximum plantar contact area in hemiplegic stroke patients with pes equinovarus. Jpn J Compr Rehabil Sci 2020; 11: 85-90.Objectives: To quantitatively demonstrate the therapeutic effects of two doses of botulinum toxin type A (BoNT-A) on pes equinovarus in hemiplegic stroke patients.Methods: The subjects of this study included eight chronic stroke patients who received two BoNT-A doses (mean dose interval: 136.0 (10.5) days) from April 2011 to March 2013 and underwent a sheet-type weight-bearing lower limb test. The maximum plantar contact area on the paralyzed side, ratio of maximum plantar contact areas on the paralyzed and nonparalyzed sides, and Modified Ashworth Scale (MAS) were measured before BoNT-A administration and 4 weeks after both the first and second doses. Results: A significant increase in the maximum plantar contact area was observed after administration of the second dose compared to that of the first dose on the paralyzed side. Additionally, a significant increase was observed in the ratio of paralyzed/non-paralyzed maximum plantar contact areas after the administration of both the first and second doses compared to that before BoNT-A administration. MAS was observed to decline significantly after the administration of both the first and second doses compared to that prior to BoNT-A administration.Conclusions: We suggest that comparison of the plantar contact area is useful for assessing the therapeutic effects of BoNT-A doses on pes equinovarus in hemiplegic stroke patients.