Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients - A distinct clinicopathologic and molecular disease entity
Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients - A distinct clinicopathologic and molecular disease entity
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DOI：
10.1097/00000478-200311000-00010
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发表时间：
2003-11-01
影响因子：
5.6
通讯作者：
Lu, DW
中科院分区：
文献类型：
--
作者：
El-Mofty, SK;Lu, DW
头颈部鳞状细胞癌通常影响60岁及以上的患者，特别是那些有长期酗酒和吸烟史的患者。即使在没有已知危险因素的情况下，癌症也很少发生在年轻人中。本研究的目的是探讨这些肿瘤与人乳头状瘤病毒（HPV）之间的可能关系。本文报告33例40岁以下的头颈部鳞状细胞癌，其中口腔癌15例，扁桃体癌11例，喉癌7例。聚合酶链反应检测10例扁桃体癌和2例喉癌中的HPV DNA，而口腔肿瘤中无HPV DNA。在12例HPV阳性肿瘤中，11例为HPV 16，1例为HPV 31。HPV阳性肿瘤具有明显的非角化基底细胞形态，与常规角化HPV阴性癌相比，它们与p16抗体呈弥漫性强染色，具有较高的Ki-67和较低的p53染色评分。结论是，在年轻患者中，高危型HPV，特别是HPV 16，与扁桃体鳞状细胞癌和一些喉肿瘤病例密切相关，但与口腔肿瘤无关。HPV阳性癌具有独特的组织病理学和免疫表型特征。
Squamous cell carcinoma of the head and neck commonly affects patients in their sixth decade and older, particularly those with a prolonged history of alcohol and tobacco abuse. Less frequently, carcinomas occur in young individuals even in the absence of known risk factors. The purpose of this study is to investigate a possible relationship between these tumors and human papilloma virus (HPV). Thirty-three cases of squamous cell carcinoma of the head and neck in young patients under the age of 40 years were studied: 15 oral, 11 tonsillar, and 7 laryngeal. HPV DNA was detected by polymerase chain reaction in 10 tonsillar and 2 laryngeal carcinomas and in none of the oral tumors. Of the 12 HPV-positive tumors, 11 were HPV 16 and 1 was HPV31. HPV-positive tumors had a distinct nonkeratinizing basal cell morphology, they stained diffusely and strongly with p16 antibodies, had higher Ki-67 and lower p53 staining scores as compared with the conventional keratinizing HPV negative carcinomas. It is concluded that in young patients high-risk HPV, particularly HPV 16, is strongly associated with tonsillar squamous cell carcinoma and some cases of laryngeal, but not oral, tumors. The HPV-positive carcinomas have a distinct histopathologic and immunophenotypic features.