Infectivity of symptomatic and asymptomatic Plasmodium vivax infections to a Southeast Asian vector, Anopheles dirus
Infectivity of symptomatic and asymptomatic Plasmodium vivax infections to a Southeast Asian vector, Anopheles dirus
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DOI：
10.1016/j.ijpara.2016.10.006
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发表时间：
2017-02-01
影响因子：
4
通讯作者：
Sattabongkot, Jetsumon
中科院分区：
文献类型：
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作者：
Kiattibutr, Kirakorn;Roobsoong, Wanlapa;Sattabongkot, Jetsumon
间日疟原虫现在是大多数非洲以外地区引起疟疾感染和疾病的主要物种，但对其从人到蚊子的传播效率知之甚少。由于流行地区的大多数疟原虫感染是低密度和无症状的，因此重要的是评估这些感染的传播情况。采用膜摄食装置，对94例自然间日疟原虫感染患者的血液样本进行了摄食。我们发现蚊子的感染率与血寄生虫血症呈正相关，当血寄生虫血症为10 ~ 10只/亩时，感染率开始上升，低于这个阈值，蚊子感染是罕见的，与卵囊相关的很少。这些发现为评估人类传播库和建立必要的诊断敏感性以确定对蚊子最具感染性的个体提供了有用的信息。(C) 2016年由Elsevier Ltd代表澳大利亚寄生虫学学会出版。
Plasmodium vivax is now the predominant species causing malarial infection and disease in most non African areas, but little is known about its transmission efficiency from human to mosquitoes. Because the majority of Plasmodium infections in endemic areas are low density and asymptomatic, it is important to evaluate how well these infections transmit. Using membrane feeding apparatus, Anopheles dirus were fed with blood samples from 94 individuals who had natural P. vivax infections with parasitemias spanning four orders of magnitude. We found that the mosquito infection rate was positively correlated with blood parasitemia and that infection began to rise when parasitemia was >10 parasites/mu l Below this threshold, mosquito infection is rare and associated with very few oocysts. These findings provide useful information for assessing the human reservoir of transmission and for establishing diagnostic sensitivity required to identify individuals who are most infective to mosquitoes. (C) 2016 Published by Elsevier Ltd on behalf of Australian Society for Parasitology.