Epigenetic analysis of kinetochore assembly on variant human centromeres.
Epigenetic analysis of kinetochore assembly on variant human centromeres.
复制标题
变异人类着丝粒着丝粒组装的表观遗传分析。
DOI：
10.1016/s0168-9525(01)02283-1
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Warburton,PE
中科院分区：
文献类型：
--
作者：
Warburton,PE
人类着丝粒的形成涉及有丝分裂动粒在含有间期前动粒的染色体位置上的组装。免疫荧光分析的两个功能匡威的人类着丝粒变体，新着丝粒和非活性着丝粒，已被用来评估超过24个着丝粒蛋白的功能意义，提供重要的洞察着丝粒形成和着丝粒装配的表观遗传学。
Human centromere formation involves the assembly of the mitotic kinetochore onto chromosomal locations that contain the interphase prekinetochore. Immunofluorescent analysis of two functionally converse human centromere variants, neocentromeres and inactive centromeres, has been used to evaluate the functional significance of over 24 centromere proteins, providing important insight into the epigenetics of centromere formation and kinetochore assembly.