A comparative study of risk factors and prognostic features between symptomatic and screen detected breast cancer
A comparative study of risk factors and prognostic features between symptomatic and screen detected breast cancer
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DOI：
10.1016/j.ejso.2007.03.025
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发表时间：
2008-02-01
期刊：
影响因子：
3.8
通讯作者：
Kell, M. R.
中科院分区：
文献类型：
--
作者：
Burke, J. P.;Power, C.;Kell, M. R.
目的：比较筛查发现乳腺癌（SDBC）和经病理证实的乳腺癌（SBC）的预后因素。评估了多种临床患者因素，包括组织病理学特征。使用盖尔模型每个病人的风险发展乳腺癌的计算和这些数据进行了检查组之间的差异groups.Results：有没有差异，在平均年龄的患者介绍或在乳腺癌的发展风险组之间（2.2%与2.2%，SDBC与SBC，精算风险的癌症在5年）。SDBC患者的分级显著较低，（1.95 vs. 2.44，SDBC vs. SBC，P < 0.05），肿瘤较小（15.4 mm vs.29.3 mm，SDBC vs. SBC，P < 0.05）和较高的雌激素水平孕酮受体阳性率为75%，P <0.05。当使用诺丁汉预后指数进行比较时，SDBC与更好的预后相关（r =-0.444，P < 0.001）。结论：尽管两组具有相似的人口统计学特征和风险，但SDBC患者似乎具有更有利的预后特征。这对乳腺癌全身治疗的应用具有意义，并支持SDBC是一种更惰性的疾病形式的观察结果。(C)2007爱思唯尔有限公司保留所有权利。
Aims: To compare prognostic factors in screen detected breast cancer (SDBC) and symptomatically presenting breast cancer (SBC).Methods: Data were examined on 100 SDBC and 100 SBC. Multiple clinical patient factors were assessed including histopathological features. Using the Gail model each patient's risk of developing breast cancer was calculated and these data were examined for differences between groups.Results: There was no difference in the mean age of patient presentation or in the risk of breast cancer development between groups (2.2% vs. 2.2%, SDBC vs. SBC, actuarial risk of cancer at 5 years). SDBC patients had a significantly lower grade (1.95 vs. 2.44, SDBC vs. SBC, P < 0.05), a smaller size of tumour (15.4 mm vs. 29.3 mm, SDBC vs. SBC, P < 0.05) and a higher rate of oestrogen (94% vs. 81%, P < 0.05) and progesterone (75% vs. 52%, P < 0.05) receptor positivity. When compared using the Nottingham Prognostic Index, SDBC was associated with a better prognosis (r = -0.444, P < 0.001).Conclusions: Though both groups have similar demographics and risk, SDBC patients appear to have more favourable prognostic features. This has implications for the application of systemic therapy in breast cancer and supports the observation that SDBC is a more indolent form of disease. (C) 2007 Elsevier Ltd. All rights reserved.