Environment, lifestyle and male infertility
Environment, lifestyle and male infertility
复制标题
DOI：
10.1053/beem.2000.0093
复制
发表时间：
2000-09-01
影响因子：
7.4
通讯作者：
Sharpe, RM
中科院分区：
文献类型：
--
作者：
Sharpe, RM
我们对环境和生活方式因素对精子数量和生育能力的重要性的理解受到男性之间和射精之间精子数量的极端差异的限制。造成这种差异的因素为理解真正影响精子数量的因素提供了关键。讨论了各种因素的相对重要性以及它们影响精子数量的途径。最重要的是支持细胞数量、射精频率、季节、影响阴囊发热的因素（例如坐着的时间）、生殖道疾病的过去史和年龄。讨论了通常认为会影响精子数量的其他环境因素（暴露于杀虫剂或内分泌干扰物）的可能作用，尽管缺乏这些因素产生重大影响的证据。研究表明，生活方式的改变，尤其是坐着的时间的改变，将在未来十年对越来越多的男性的精子产生不利影响。
Our understanding of the importance of environmental and lifestyle factors on sperm count and fertility is constrained by the extreme variation in sperm count between men and between ejaculates. The factors responsible for this variation provide a key to understanding what factors actually affect the sperm count. The relative importance of the various factors and the pathways via which they affect sperm count are discussed. The most important are Sertoli cell number, ejaculatory frequency, season, factors affecting scrotal heating (e.g. the time spent seated), a past history of reproductive tract disorders and ageing. The possible role of other environmental factors commonly supposed to affect sperm count (exposure to pesticides or endocrine disrupters) is discussed, although the evidence for a major influence of such factors is lacking. It is suggested that lifestyle changes, especially in the time spent seated, will exert an adverse effect on sperm production in a progressively larger group of men over the next decade.