Variable place-cell coupling to a continuously viewed stimulus: evidence that the hippocampus acts as a perceptual system.
Variable place-cell coupling to a continuously viewed stimulus: evidence that the hippocampus acts as a perceptual system.
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可变位置细胞与连续观察的刺激的耦合：海马体充当感知系统的证据。
DOI：
10.1098/rstb.1997.0137
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Muller,RU
中科院分区：
文献类型：
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作者：
Rotenberg,A;Muller,RU
感知的一个关键特征是，对一个单一的、持续可用的刺激的解释可以不时地改变。这方面的看法是很好地说明了使用模糊的数字，可以看到在两个不同的方式。当人们看到这样的刺激时，他们几乎普遍地将他们所看到的描述为在两种状态之间跳跃。如果我们同意这种知觉现象与神经细胞的活动有因果关系，那么状态跳跃就必须与神经系统中某个地方的神经活动变化相结合，本文所描述的实验表明，海马位置细胞是知觉系统的一部分。在大鼠上进行的“提示卡旋转”实验中，在大鼠存在的情况下，改变圆柱体壁上突出的视觉刺激的角位置。三个主要结果如下。(i)如果线索旋转180°，位置细胞放电场保持静止，从而改变了线索和场之间的关系。(ii)当球杆旋转45 °时，射击场旋转45 °，并且场与卡之间的关系保持不变。(iii)如果球杆首先旋转180°，然后以一系列45°的步骤旋转，则当牌回到其原始位置时，场在相对于牌的不同角度位置处结束。因此，位置细胞可以以两种不同的方式对连续观察的刺激做出反应。它的结论是，位置细胞显示，海马映射系统也具有预期的感知系统的属性。
A key feature of perception is that the interpretation of a single, continuously available stimulus can change from time to time. This aspect of perception is well illustrated by the use of ambiguous figures that can be seen in two different ways. When people view such a stimulus they almost universally describe what they are seeing as jumping between two states. If it is agreed that this perceptual phenemonon is causally linked to the activity of nerve cells, the state jumps would have to occur in conjunction with changes in neural activity somewhere in the nervous system.The experiments described in this paper suggest that hippocampal place cells are part of a perceptual system. Variations were made of a ‘cue–card rotation’ experiment on rats in which the angular position of a prominent visual stimulus on the wall of cylinder is changed in the rat's presence. The three main results are as follows. (i) Place–cell firing fields remain stationary if the cue is rotated by 180° so that the relation between the cue and the field is altered. (ii) Firing fields rotate by 45° when the cue is rotated by 45°and the relation between the field and the card is maintained. (iii) If the cue is first rotated by 180°and then rotated in a series of 45° steps, the field finishes at a different angular position relative to the card when the card is back in its original position. Thus, place cells can fire in two different ways in reponse to a continuously viewed stimulus. It is concluded that place cells reveal that the hippocampal mapping system also has properties expected of a perceptual system.