Maternal urinary cadmium concentrations in relation to preterm birth in the Healthy Baby Cohort Study in China
Maternal urinary cadmium concentrations in relation to preterm birth in the Healthy Baby Cohort Study in China
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中国健康婴儿队列研究中母亲尿镉浓度与早产的关系
DOI：
10.1016/j.envint.2016.06.003
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发表时间：
2016
影响因子：
11.8
通讯作者：
Shunqing Xu
中科院分区：
文献类型：
--
作者：
Jie Yang;Wenqian Huo;Bin Zhang;Tongzhang Zheng;Yuanyuan Li;Xinyun Pan;Wenyu Liu;Huailong Chang;Minmin Jiang;Aifen Zhou;Zhengmin Qian;Yanjian Wan;Wei Xia;Shunqing Xu
研究背景产前接触镉(Cd)与不良出生结局有关，但以往的研究结果并不一致。本研究的目的是评估产前镉暴露与分娩结局的关系。方法本研究于2012年9月至2014年10月在武汉市中国健康婴儿队列中招募的5364名单胎活产孕妇中进行。孕周(以天为单位)是使用女性最后一次月经(LMP)和超声波数据来估计的。所有的出生结局，包括出生体重和出生长度，在出生后1小时内通过标准化程序在医院测量。结果孕妇尿镉的几何平均值为0.5 5(0.0 1~2.85)μg/g肌酐。我们发现，孕妇尿镉浓度(μg/g肌酐)每增加1n个单位，就与胎龄下降有关[调整后的β=−=0.77天；95%可信区间(CI)：所有婴儿的−为1.15，−为0.39；−为0.77；95%CI为：−为1.29，−为0.25；−为0.80；95%CI：−为1.35，−为0.25]。早产的可能性增加与单位尿镉(μg/g肌酐)增加相关[调整后的优势比(OR)=1.78；95%CI：1.45，2.19(所有婴儿；1.97；95%CI：1.46，2.65男孩；1.67；95%CI：1.24，2.25女孩])。母亲尿Cd与低出生体重儿(LBW)和小于胎龄儿(SGA)无明显相关性。结论孕妇孕期接触Cd可降低孕周，增加发生肺结核的可能性。
BackgroundPrenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. The aim of this study was to evaluate the association between prenatal Cd exposure and birth outcomes.MethodsThis study was conducted in 5364 pregnant women with a live singleton birth, who were recruited between September 2012 and October 2014 in the Healthy Baby Cohort (HBC) in Wuhan, China. Gestational age (in days) was estimated using both the woman's last menstrual period (LMP) and ultrasound data. All the birth outcomes including birth weight and birth length were measured in the hospital within one hour after birth through standardized procedures. Cd was measured in maternal urine collected before delivery with inductively coupled plasma mass spectrometry.ResultsThe geometric mean of Cd concentration in maternal urine was 0.55 (range 0.01–2.85) μg/g creatinine. We found each ln-unit increase in Cd concentration (μg/g creatinine) in maternal urine was associated with decreased gestational age [adjusted β = − 0.77 day; 95% confidence interval (CI): − 1.15, − 0.39 for all infants; − 0.77; 95% CI: − 1.29, − 0.25 for boys; and − 0.80; 95% CI: − 1.35, − 0.25 for girls]. Increased likelihood of preterm birth (PTB) was associated with ln-unit increase in urinary Cd (μg/g creatinine) [adjusted odds ratio (OR) = 1.78; 95% CI: 1.45, 2.19 for all infants; 1.97; 95% CI: 1.46, 2.65 for boys; and 1.67; 95% CI: 1.24, 2.25 for girls]. Maternal urinary Cd was not significantly associated with low birth weight (LBW) and small for gestational age (SGA).ConclusionsMaternal exposure to Cd during pregnancy was associated with decreased gestational age and increased likelihood of PTB.