Structure of the interface between rabbit cortical bone and implants of gold, zirconium and titanium
Structure of the interface between rabbit cortical bone and implants of gold, zirconium and titanium
复制标题
DOI：
10.1023/a:1018579605426
复制
发表时间：
1997-11-01
影响因子：
3.7
通讯作者：
Kasemo, B
中科院分区：
文献类型：
--
作者：
Thomsen, P;Larsson, C;Kasemo, B
生物材料和组织之间的相互作用的表面性质（化学和结构）的作用还不清楚。在本研究中，将由钛、锆（具有表面氧化物的过渡金属）和金（金属表面）制成的植入物插入家兔胫骨中。光学显微镜（LM）形态测定显示，1个月和6个月后，与钛和锆植入物相比，金植入物螺纹内的骨量较少，骨-植入物接触程度较低，两者之间没有差异。这些定量差异的支持LM和超微结构观察的接口。此外，超微结构观察结果表明，位于植入物和钙化骨之间的非胶原无定形材料层在锆周围比钛植入物周围明显更厚。讨论了可能导致不同材料表面周围骨骼形态差异的因素。
The role of surface properties (chemical and structural) for the interaction between biomaterials and tissue is not yet understood. In the present study, implants made of titanium, zirconium (transition metals with surface oxides) and gold (metallic surface) were inserted into the rabbit tibia. Light microscopic (LM) morphometry showed that after 1 and 6 mo the gold implants had less amount of bone within the threads and a lower degree of bone-implant contact than the titanium and zirconium implants, which did not differ from each other. These quantitative differences were supported by LM and ultrastructural observations of the interface. The ultrastructural observations in addition demonstrated that the layer of non-collagenous amorphous material located between the implant and the calcified bone was appreciably thicker around zirconium than around titanium implants. The factors potentially responsible for the observed morphological differences in the bone around the different material surfaces are discussed.