Allitridi inhibits transient outward potassium currents in human atrial myocytes
Allitridi inhibits transient outward potassium currents in human atrial myocytes
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Allitridi 抑制人心房肌细胞中的瞬时外向钾电流
DOI：
10.1111/j.1440-1681.2011.05511.x
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发表时间：
2011-05-01
影响因子：
2.9
通讯作者：
Yu, Xi-Yong
中科院分区：
文献类型：
--
作者：
Deng, Chun-Yu;Rao, Fang;Yu, Xi-Yong
1.据报道，大蒜素是一种从大蒜中提取的活性化合物，具有多种心血管作用。 然而，大蒜素是否影响人心房肌细胞的主要复极电流，如瞬时外向钾电流（Ito）、超快速延迟整流钾电流（IKur）和L型钙电流（伊卡），目前尚不清楚。2.在本研究中，我们采用全细胞膜片钳记录技术研究了大蒜素对人心房肌细胞Ito、IKur、ICa和动作电位的影响。 大蒜素的这种作用呈浓度依赖性（IC_（50）= 44.9 μmol/L）。 Ito的失活被加速，电压依赖性失活电位向负方向移动。大蒜素（30 μmol/L）可显著延长人心房肌细胞动作电位时程。4.大蒜素可延长人心房肌细胞动作电位时程，但不能延长Ito和ICa。
1. It has been reported that allitridi, an active compound extracted from garlic, has many cardiovascular effects. However, it remains unknown whether allitridi affects major repolarization currents, such as the transient outward K+current (Ito), ultrarapid delayed rectifier K+current (IKur) and the L‐type Ca2+current (ICa), in human atrial myocytes.2. In the present study, we investigated the effects of allitridi onIto,IKur,ICaand the action potential in human isolated atrial myocytes using the whole‐cell patch recording technique.3. Allitridi reversibly inhibitedIto, but notIKurandICa, in human atrial myocytes. These effects of allitridi onItowere concentration dependent (IC50= 44.9 μmol/L). Inactivation ofItowas accelerated and the voltage‐dependent inactivation potential was shifted towards the negative direction. Allitridi (30 μmol/L) significantly prolonged action potential duration in human atrial myocytes.4. The results of the present study indicate that allitridi inhibitsIto, but notIKurandICa, and prolongs the action potential duration in human atrial myocytes.