Vaccines against invasive Salmonella disease: current status and future directions.
Vaccines against invasive Salmonella disease: current status and future directions.
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DOI：
10.4161/hv.29054
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发表时间：
2014
影响因子：
4.8
通讯作者：
Micoli F
中科院分区：
文献类型：
--
作者：
MacLennan CA;Martin LB;Micoli F
尽管沙门氏菌主要是肠道病原体，但它却造成了相当大但未被充分认识的全球侵袭性疾病负担。在南亚和东南亚，这表现为由伤寒和甲型副伤寒血清型引起的肠热病。在撒哈拉以南非洲，侵袭性非伤寒沙门氏菌（主要是鼠伤寒和肠炎血清型）也造成了类似的疾病负担。现有的 Ty21a 减毒活疫苗和 Vi 荚膜多糖疫苗针对伤寒沙门氏菌，对侵袭性沙门氏菌疾病负担最高的幼儿无效。经过多年缺乏对新沙门氏菌疫苗的投资，近年来新兴市场制造商、全球健康疫苗研究所和学术合作伙伴对该领域的兴趣日益浓厚。针对伤寒沙门氏菌的新型糖复合物疫苗正在与正在开发的针对其他侵袭性血清型的类似疫苗一起使用。随着其他新疫苗的研究，包括减毒活疫苗、蛋白质疫苗和 GMMA 疫苗，现在是沙门氏菌疫苗领域激动人心的时刻。
Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet under-appreciated global burden of invasive disease. In South and South-East Asia, this manifests as enteric fever caused by serovars Typhi and Paratyphi A. In sub-Saharan Africa, a similar disease burden results from invasive nontyphoidal Salmonellae, principally serovars Typhimurium and Enteritidis. The existing Ty21a live-attenuated and Vi capsular polysaccharide vaccines target S. Typhi and are not effective in young children where the burden of invasive Salmonella disease is highest. After years of lack of investment in new Salmonella vaccines, recent times have seen increased interest in the area led by emerging-market manufacturers, global health vaccine institutes and academic partners. New glycoconjugate vaccines against S. Typhi are becoming available with similar vaccines against other invasive serovars in development. With other new vaccines under investigation, including live-attenuated, protein-based and GMMA vaccines, now is an exciting time for the Salmonella vaccine field.
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影响因子：
3.8
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